SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. - Wikidata - wikimedia - TriplyDB

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.

http://www.wikidata.org/entity/Q39523760

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Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition Metabolism, longevity and epigenetics Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling.Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3 MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway.SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.Janus-faced role of SIRT1 in tumorigenesis.SIRT1 in B[a]P-induced lung tumorigenesis.Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway.Circadian rhythm connections to oxidative stress: implications for human health.The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.SIRT1 promotes metastasis of human osteosarcoma cells.Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways.SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer.Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells.p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer.

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P2860

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.

http://www.wikidata.org/entity/Q39523760

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Invasion and metastasis in pancreatic cancer

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Cancer statistics, 2008

p53, the cellular gatekeeper for growth and division

Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells

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