Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase.
about
Antiamoebic drugs for treating amoebic colitisDrug targets and mechanisms of resistance in the anaerobic protozoaA high-throughput drug screen for Entamoeba histolytica identifies a new lead and targetNew drug target in protozoan parasites: the role of thioredoxin reductaseReprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseasesHost-Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes?Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiomeNitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductaseFunctional characterization of peroxiredoxins from the human protozoan parasite Giardia intestinalisBioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genesResveratrol Induces Apoptosis-Like Death and Prevents In Vitro and In Vivo Virulence of Entamoeba histolyticaProteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative StressBiochemistry and evolution of anaerobic energy metabolism in eukaryotesCalcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BP.Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolitesEfficacy of antiamebic drugs in a mouse model.Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin AResistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.Overexpression of cysteine proteinase 2 in Entamoeba histolytica or Entamoeba dispar increases amoeba-induced monolayer destruction in vitro but does not augment amoebic liver abscess formation in gerbils.Proteomic comparison of Entamoeba histolytica and Entamoeba dispar and the role of E. histolytica alcohol dehydrogenase 3 in virulence.Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.Drug susceptibility testing of anaerobic protozoa.Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica.Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways.Trichomonas vaginalis flavin reductase 1 and its role in metronidazole resistance.Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.Iron-saturated lactoferrin and pathogenic protozoa: could this protein be an iron source for their parasitic style of life?Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines.Reactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility to nitroimidazolesKinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistanceNovel properties of photofermentative biohydrogen production by purple bacteria Rhodobacter sphaeroides: effects of protonophores and inhibitors of responsible enzymesPeroxiredoxins in parasites.Chew on this: amoebic trogocytosis and host cell killing by Entamoeba histolytica.Unexpected properties of NADP-dependent secondary alcohol dehydrogenase (ADH-1) in Trichomonas vaginalis and other microaerophilic parasitesNitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.Exploratory Investigation of Bacteroides fragilis Transcriptional Response during In vitro Exposure to Subinhibitory Concentration of Metronidazole.N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress.Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent.
P2860
Q24241818-26C49293-41FE-4DA9-8F59-D999A832A4C5Q24550694-2D0286B4-7D10-43F5-BB73-1E4594876FC0Q24623736-B6315853-4CB8-499F-820D-96989F5C4619Q26781548-65247999-FD20-4462-8B12-275E5544811EQ27003233-F64FC53C-4351-486B-9697-07BDD285C72CQ27686869-D4F5ED67-5462-427F-8A3F-C51E1D95466FQ28077685-66E7FC62-A2DB-4EDF-B11E-25735DA3BC1BQ28469267-7FEA4FD2-F260-4BE2-A11A-6B9B1DB15051Q28538547-AAE2954D-5C09-4271-A39B-02815D20D2F6Q28538611-B6BB7A3D-1324-4CAD-8A58-0214A7F73FE1Q28552069-D20A90D5-57DD-4210-B32B-C3605AAE4F6FQ28552127-4895AE0E-4CFD-4B13-8E6C-9C9FBA8482E8Q28728648-3DF85766-93DF-488C-A6C4-22C4B6E21E3AQ30310294-5F0FC048-BDA8-492F-A587-56A10E0170B5Q30387417-8E47E9B0-8123-409E-8100-314A5BAB864AQ30427465-32D38DC2-73E6-464D-AF73-331429A2819DQ30439011-27EA3617-1388-4EE0-8437-FF13BE90F025Q30528009-F5665E74-A02E-41D1-9C7F-6C2419FF64A8Q31081478-D2BBBB96-2818-479A-A357-E5FCA92A5671Q32026796-08913A4E-0941-41A4-B074-2C51BBFAA5EBQ33429948-BBFDB443-214E-462F-A1F3-1FA74FB0F945Q33798454-56DCF236-E7AA-440F-9D5D-054866E44007Q33982334-CE9EA84C-D3C6-4288-88B4-90E71726DEAAQ34113775-2F520459-A132-4294-AC5A-07223E686A1BQ34222836-7998F145-EAAE-4472-A5DE-352B310B341FQ34386410-82AD3123-F7FC-44C6-BDB2-645742C75414Q34601985-678B4808-3A6C-465A-A688-974DC93806ABQ34634555-52C40955-06BE-4A95-934C-F537EFC59B8EQ34668289-185E3659-6C96-4ACB-AFB0-F0363FEA72BAQ34724204-D20AD269-F3D8-4202-8D0D-B62AE6D6A078Q34736829-CA4CEA17-CBCF-40A6-8F4C-62804183A394Q35569960-156E0831-E479-4373-B6AE-3F58761D9046Q36023222-6565EDCF-149A-4D71-B1BE-137F4A87B2D3Q36026850-71CFE16C-DE26-4861-8B2B-806C53BAB004Q36052733-B7787A1E-6F20-4BF2-BBDD-4F37D78DCB9BQ36927883-140A26BE-EBC0-4453-867F-FC9627766880Q37037261-E59FC743-7200-4180-8179-2EB456D0005CQ37266199-AC7DE9FA-812D-4D50-B4EA-3606ED6A61B4Q37390480-DE453B37-029A-4ED2-B9B9-54CBDB9476FAQ37538663-F99CE9B8-A46F-428F-87E3-F112C36B2C51
P2860
Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@en
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@nl
type
label
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@en
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@nl
prefLabel
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@en
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@nl
P2093
P2860
P356
P1476
Metronidazole resistance in th ...... edoxin 1 and flavin reductase.
@en
P2093
Bruchhaus I
Hellberg A
Wassmann C
P2860
P304
26051-26056
P356
10.1074/JBC.274.37.26051
P407
P577
1999-09-01T00:00:00Z