Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
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Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signallingThe prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletionA novel role for copper in Ras/mitogen-activated protein kinase signaling.Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development.Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways.Transcriptional profiling of swine lung tissue after experimental infection with Actinobacillus pleuropneumoniae.SUMO wrestling with Ras.Regulation of Wnt/β-catenin signaling by posttranslational modificationsLysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β.SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cellsInverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation.Loss of SUMOylation on ATF3 inhibits proliferation of prostate cancer cells by modulating CCND1/2 activity.The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene.Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cellsModification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.SUMO modification of meninSUMO1 negatively regulates reactive oxygen species production from NADPH oxidases.The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.Detection and Functional Analysis of SUMO-Modified MEK.Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma.The post-translational modification, SUMOylation, and cancer (Review).Cooperation of deregulated Notch signaling and Ras pathway in human hepatocarcinogenesis.SUMOylation of the inducible (c-Fos:c-Jun)/AP-1 transcription complex occurs on target promoters to limit transcriptional activation.
P2860
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P2860
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@en
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@nl
type
label
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@en
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@nl
prefLabel
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@en
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@nl
P2093
P2860
P356
P1433
P1476
Oncogenic Ras abrogates MEK SU ...... thway and cell transformation.
@en
P2093
Haruo Saito
Mutsuhiro Takekawa
Pauline O'Grady
Yuji Kubota
P2860
P2888
P304
P356
10.1038/NCB2169
P577
2011-02-20T00:00:00Z