Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
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Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in HumansThe sweet trap in tumors: aerobic glycolysis and potential targets for therapyMYC, Metabolism, and CancerLactate dehydrogenase A in cancer: a promising target for diagnosis and therapyNovel therapeutic targets of tumor metabolismBioactive heterocycles containing endocyclic N-hydroxy groupsStructures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound formsEpilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsyPhosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasisQuantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewQuinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells.Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesisMetabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells.Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cellsDetection of protein-small molecule binding using a self-referencing external cavity laser biosensor.Inhibition of lactate dehydrogenase activity as an approach to cancer therapy.Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHASynthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and deathA comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line modelsAnticancer agents that counteract tumor glycolysis.Targeting the metabolic microenvironment of tumors.Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffoldsExogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate.Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.Small-molecule inhibitors of human LDH5.Therapeutic targets in cancer cell metabolism and autophagy.Conceptual framework for cutting the pancreatic cancer fuel supply.Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target.Targeting lactate metabolism for cancer therapeutics.Metabolic implication of tumor:stroma crosstalk in breast cancer.Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery.Metabolic modulation of cancer: a new frontier with great translational potential.Prognostic role of lactate dehydrogenase in solid tumors: a systematic review and meta-analysis of 76 studies.Synthetic applications of hypophosphite derivatives in reduction.The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1.Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice
P2860
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P2860
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Discovery of N-hydroxyindole-b ...... n agents against cancer cells.
@en
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A
@nl
type
label
Discovery of N-hydroxyindole-b ...... n agents against cancer cells.
@en
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A
@nl
prefLabel
Discovery of N-hydroxyindole-b ...... n agents against cancer cells.
@en
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A
@nl
P2093
P50
P356
P1476
Discovery of N-hydroxyindole-b ...... on agents against cancer cells
@en
P2093
Emilia C Calvaresi
Godefridus J Peters
Leticia G León
Marco Macchia
Mario Lanza
Paul J Hergenrother
Rahul Palchaudhuri
Sarabindu Roy
P304
P356
10.1021/JM101007Q
P407
P50
P577
2011-02-18T00:00:00Z