Functional modulation of AMP-activated protein kinase by cereblon.
about
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideWhat is the functional role of the thalidomide binding protein cereblon?Identification of recently selected mutations driven by artificial selection in hanwoo (korean cattle).Functional effects of a pathogenic mutation in Cereblon (CRBN) on the regulation of protein synthesis via the AMPK-mTOR cascade.Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system.Protein ubiquitination in lymphoid malignancies.RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2.Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma.The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride ChannelsStructural dynamics of the cereblon ligand binding domain.Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase functionDisruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice.Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition.Physical activity-associated gene expression signature in nonhuman primate motor cortex.Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma.Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth.Cereblon in health and disease.Modulation of cereblon levels by anti-myeloma agents.The molecular mechanism of thalidomide analogs in hematologic malignancies.In Vitro Methods to Study AMPK.Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma.Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.Trial Watch: Lenalidomide-based immunochemotherapy.Screening and identification of host proteins interacting with Theileria annulata cysteine proteinase (TaCP) by yeast-two-hybrid system.Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation.The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity.Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
P2860
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P2860
Functional modulation of AMP-activated protein kinase by cereblon.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Functional modulation of AMP-activated protein kinase by cereblon.
@en
Functional modulation of AMP-activated protein kinase by cereblon.
@nl
type
label
Functional modulation of AMP-activated protein kinase by cereblon.
@en
Functional modulation of AMP-activated protein kinase by cereblon.
@nl
prefLabel
Functional modulation of AMP-activated protein kinase by cereblon.
@en
Functional modulation of AMP-activated protein kinase by cereblon.
@nl
P2093
P1476
Functional modulation of AMP-activated protein kinase by cereblon.
@en
P2093
Chul-Seung Park
Hyunyoung Kim
Jongwon Lee
Kwang Min Lee
Sooyeon Jo
P304
P356
10.1016/J.BBAMCR.2011.01.005
P577
2011-01-11T00:00:00Z