An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?
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Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsThe Essential Medicinal Chemistry of CurcuminBioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensisThe 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents.The essential roles of chemistry in high-throughput screening triageSynthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells.Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments.Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptorThe Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention ActivitiesChemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease preventionThe cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathwaysVCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis.Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMRGrowth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin.Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.Plant volatiles: production, function and pharmacology.5,6-Dehydrokawain from Alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation.Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor.The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols.Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen.Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channelsMichael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.Opening or closing the lock? When reactivity is the key to biological activity.Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis.Reactivity assessment of chalcones by a kinetic thiol assay.Umbellulone modulates TRP channels.2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.Exploring of drug leads from diversity-oriented Michael-acceptor library derived from natural products.Ligustilide: a novel TRPA1 modulator.Tandem Wittig/Diels-Alder diversification of genetically encoded peptide libraries.Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.Recent developments with rhodanine as a scaffold for drug discovery.The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type-specific induction of apoptosis and mitotic catastrophe.
P2860
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P2860
An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
An NMR spectroscopic method to ...... acceptors for drug discovery?
@en
An NMR spectroscopic method to ...... acceptors for drug discovery?
@nl
type
label
An NMR spectroscopic method to ...... acceptors for drug discovery?
@en
An NMR spectroscopic method to ...... acceptors for drug discovery?
@nl
prefLabel
An NMR spectroscopic method to ...... acceptors for drug discovery?
@en
An NMR spectroscopic method to ...... acceptors for drug discovery?
@nl
P2093
P50
P356
P1476
An NMR spectroscopic method to ...... acceptors for drug discovery?
@en
P2093
Federica Pollastro
Luciano De Petrocellis
Orazio Taglialatela-Scafati
P304
P356
10.1002/ANIE.201005959
P407
P577
2011-01-01T00:00:00Z