about
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.Allosteric functioning of dimeric class C G-protein-coupled receptors.Metabotropic receptors for glutamate and GABA in pain.Dimers and beyond: The functional puzzles of class C GPCRs.Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulatorDynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.Allosteric modulation of metabotropic glutamate receptors by chloride ions.Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle alpha 1s subunit as expressed in mouse L cells.Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective.An allosteric modulator to control endogenous G protein-coupled receptors with light.Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis.Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.Magnesium ions promote assembly of channel-like structures from beticolin 0, a non-peptide fungal toxin purified from Cercospora beticola.Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology.OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom.D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.Determination of the absolute configuration of phosphinic analogues of glutamateChloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptorsExploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptorα-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4
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description
hulumtues
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researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Cyril Goudet
@ast
Cyril Goudet
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Cyril Goudet
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Cyril Goudet
@nl
Cyril Goudet
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type
label
Cyril Goudet
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Cyril Goudet
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Cyril Goudet
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Cyril Goudet
@nl
Cyril Goudet
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prefLabel
Cyril Goudet
@ast
Cyril Goudet
@en
Cyril Goudet
@es
Cyril Goudet
@nl
Cyril Goudet
@sl
P214
P106
P1153
6603247605
P21
P213
0000 0003 9023 8989
P214
P2798
P31
P496
0000-0002-8255-3535
P569
1970-12-02T00:00:00Z
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viaf-283830677