The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma.

The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma.

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http://www.wikidata.org/entity/Q39668891
Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophagesNeutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastaseLung injury induced by leukocytic proteases.Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysemaA model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.Studies on the pathogenesis of the adult respiratory distress syndrome.Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro.Experimental pulmonary inflammatory injury in the monkey.
P2860

The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma.

Item
http://www.wikidata.org/entity/Q39668891
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
The effects in vivo and in vit ...... inhibiting activity of plasma.
@en
The effects in vivo and in vit ...... inhibiting activity of plasma.
@nl
type
label
The effects in vivo and in vit ...... inhibiting activity of plasma.
@en
The effects in vivo and in vit ...... inhibiting activity of plasma.
@nl
prefLabel
The effects in vivo and in vit ...... inhibiting activity of plasma.
@en
The effects in vivo and in vit ...... inhibiting activity of plasma.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
The effects in vivo and in vit ...... inhibiting activity of plasma.
@en
P2093
P304
P31
P356
10.1164/ARRD.1979.119.6.953
P433
P478
P577
P698