Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.

Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.

Item
http://www.wikidata.org/entity/Q39671969
Discovery of Disubstituted Imidazo[4,5- b ]pyridines and Purines as Potent TrkA InhibitorsThe lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancerPhase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignanciesCell cycle proteins as promising targets in cancer therapyPerineural invasion and associated pain in pancreatic cancer.Emerging cell-cycle inhibitors for pancreatic cancer therapy.Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Inhibitors of cyclin-dependent kinases as cancer therapeutics.Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier.Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential.
P2860

Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.

Item
http://www.wikidata.org/entity/Q39671969
description
2010 nî lūn-bûn
@nan
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
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2010年论文
@zh-cn
name
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@en
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@nl
type
label
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@en
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@nl
prefLabel
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@en
Dual targeting of CDK and trop ...... d-spectrum antitumor efficacy.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
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Dual targeting of CDK and trop ...... ad-spectrum antitumor efficacy
@en
P2093
P304
P31
P356
10.1158/1535-7163.MCT-10-0190
P433
P478
P50
P577
P698