Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
about
Biosynthesis and function of polyacetylenes and allied natural productsComparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathwaysStructure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog FoldTowards prediction of metabolic products of polyketide synthases: an in silico analysisC-S bond cleavage by a polyketide synthase domain.Cloning, sequencing, and functional analysis of an iterative type I polyketide synthase gene cluster for biosynthesis of the antitumor chlorinated polyenone neocarzilin in "Streptomyces carzinostaticus"Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.Biosynthetic studies of aziridine formation in azicemicins.Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690.Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen speciesBiosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisDraft Genome Sequence of Marine-Derived Streptomyces sp. TP-A0873, a Producer of a Pyrrolizidine Alkaloid Bohemamine.The enzymology of combinatorial biosynthesis.Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.Type I polyketide synthases that require discrete acyltransferases.Less than the sum of its parts, a leinamycin precursor has superior properties.Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis.Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.Biosynthesis of polyketides by trans-AT polyketide synthases.Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Characterization of gamma-butyrolactone autoregulatory signaling gene homologs in the angucyclinone polyketide WS5995B producer Streptomyces acidiscabiesThe tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.
P2860
Q24644952-161C63E2-0965-44FE-81FA-B9A222A49876Q27642846-E980587C-E2EB-4A14-8053-966325C4FF8CQ27675905-8EE3F483-5C2C-41FF-9C3C-4602EF44FAEAQ28475181-B5A48AC8-5D06-4811-9E0D-2B4AE1A7287BQ30984909-176EC5EE-2202-4413-A9C5-6A75E3CDC07CQ31108104-FB41EE3F-777F-4754-81AE-2EE5C02BDE4AQ33215034-46F22EE2-AC4A-432C-944A-F52C50527BD9Q33392888-136D2423-FE7D-4930-85A8-379A09FFD658Q33552290-0E4ED0C1-0C2C-47F1-921E-8F759B195C95Q33834252-9FD8BC43-5002-4F3D-B1D1-7C4A9C3AADFEQ34479821-DDE8D158-5A5A-4F59-BAC4-E3075C280329Q34680553-9A31B43D-010F-4F1B-BB15-EE66EE49EEBAQ34782058-5C899FE4-3EF0-4723-BED1-39ACA241F640Q34867101-5CD7DB0E-F5E8-41AA-AEB4-9393448D432AQ35104247-3B0F1685-F573-4F1C-B067-4FD3C130A33EQ35188415-A4DE8BE1-2705-4FE1-BD2E-55050CED3CA4Q35662818-7A080817-CF18-4BF1-8D52-C23D4306EFECQ35781712-AC33B967-2B0B-4083-AB12-FB1307C764C7Q35845985-EE6AD41E-55BF-45EB-8D10-CB5325582789Q36153240-FD3F2292-5108-4DEF-8CCA-D24EF41A296BQ36435230-6DE4D22D-90F6-4606-8E0F-269A77C3B6E7Q36965969-2842DF83-882B-4E02-89CB-BE22BF114285Q37230944-243BB3D6-EFFC-40C7-A246-13229F7D0594Q38628326-D87A583B-1CED-44F9-96AB-7967A1157267Q38675125-99AC86DD-AA9F-4903-BF76-26C5AFA06F70Q39218600-619B5264-4E2C-4649-8AC9-A75C6B17FFBDQ42578945-D0B74EFF-6F7B-4F6D-A018-36961B2FCE12Q42608593-089777D7-5FF7-4F28-AABE-2E0A498859EBQ46971666-63DB2F8A-47EC-4756-A04E-AC88D7BD8052Q49899943-F1F5C146-7C11-4000-933F-DEB927DCCF68
P2860
Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@en
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@nl
type
label
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@en
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@nl
prefLabel
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@en
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@nl
P2093
P2860
P1476
Identification and localizatio ...... eptomyces atroolivaceus S-140.
@en
P2093
Gong-Li Tang
Yi-Qiang Cheng
P2860
P304
P356
10.1128/JB.184.24.7013-7024.2002
P407
P577
2002-12-01T00:00:00Z