LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
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A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporterA Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial RespirationOpiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies.Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound.HIF-1α pathway: role, regulation and intervention for cancer therapy.Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma.Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α.Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy.Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction.Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy.Glioblastoma, cancer stem cells and hypoxia.Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).Suppression of T-cell responses by tumor metabolites.HIFs, angiogenesis, and cancer.Chemical biology approach for the development of hypoxia inducible factor (HIF) inhibitor LW6 as a potential anticancer agent.Targeting cancer cell mitochondria as a therapeutic approach: recent updates.Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals.Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth.Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein.HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies.LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells.Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes.Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.Mincle Signaling Promotes Con A Hepatitis.Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A "structure-activity relationship" perspective.Target validation using in-cell small molecule clickable imaging probes
P2860
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P2860
LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@en
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@nl
type
label
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@en
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@nl
prefLabel
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@en
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@nl
P2093
P1476
LW6, a novel HIF-1 inhibitor, ...... L in a colon cancer cell line.
@en
P2093
Eun-Gyeong Yang
Hwan-Mook Kim
Jung Eun Kang
Jung-Jun Lee
Kyeong Lee
Kyung Bin Song
Kyung-Sook Chung
Moo Rim Kang
P304
P356
10.1016/J.BCP.2010.06.018
P407
P577
2010-06-23T00:00:00Z