Restriction of viral replication by mutation of the influenza virus matrix protein.
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Recent progress in structure-based anti-influenza drug designCrystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.Influenza virus hemagglutinin (H3 subtype) requires palmitoylation of its cytoplasmic tail for assembly: M1 proteins of two subtypes differ in their ability to support assembly.YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66.Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza virus infection.Molecular signature of high yield (growth) influenza a virus reassortants prepared as candidate vaccine seeds.Introduction of a temperature-sensitive phenotype into influenza A/WSN/33 virus by altering the basic amino acid domain of influenza virus matrix protein.The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations.Protein-lipid interactions critical to replication of the influenza A virus.A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence.Influenza a viruses with mutations in the m1 helix six domain display a wide variety of morphological phenotypes.The lack of an inherent membrane targeting signal is responsible for the failure of the matrix (M1) protein of influenza A virus to bud into virus-like particles.Basic residues of the helix six domain of influenza virus M1 involved in nuclear translocation of M1 can be replaced by PTAP and YPDL late assembly domain motifs.Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS.Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.
P2860
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P2860
Restriction of viral replication by mutation of the influenza virus matrix protein.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Restriction of viral replication by mutation of the influenza virus matrix protein.
@en
Restriction of viral replication by mutation of the influenza virus matrix protein.
@nl
type
label
Restriction of viral replication by mutation of the influenza virus matrix protein.
@en
Restriction of viral replication by mutation of the influenza virus matrix protein.
@nl
prefLabel
Restriction of viral replication by mutation of the influenza virus matrix protein.
@en
Restriction of viral replication by mutation of the influenza virus matrix protein.
@nl
P2860
P1433
P1476
Restriction of viral replication by mutation of the influenza virus matrix protein.
@en
P2093
Teresa Liu
Zhiping Ye
P2860
P304
13055-13061
P356
10.1128/JVI.76.24.13055-13061.2002
P407
P577
2002-12-01T00:00:00Z