Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair
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Improving the efficacy of chemoradiation with targeted agentsUpdate on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatmentESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)†A phase I-II evaluation of veliparib (NSC #737664), topotecan, and filgrastim or pegfilgrastim in the treatment of persistent or recurrent carcinoma of the uterine cervix: an NRG Oncology/Gynecologic Oncology Group studySequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer.Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study.Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibitionCombined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.Targeting DNA-PKcs and telomerase in brain tumour cells.Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition.Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaksSynthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.The ups and downs of DNA repair biomarkers for PARP inhibitor therapiesPre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repairInhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts.An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma.BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8,988 patients with prostate cancer.Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break RepairThe development of PARP inhibitors in ovarian cancer: from bench to bedsideRadiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent CellsHarnessing synthetic lethal interactions in anticancer drug discoveryHypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) EraDiminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.Strategies for optimizing the response of cancer and normal tissues to radiation.DNA repair in cancer: emerging targets for personalized therapy.Selective tumor killing based on specific DNA-damage response deficiencies.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma.The potential of PARP inhibitors in neuro-oncology.Radiation oncology in vitro: trends to improve radiotherapy through molecular targets.Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.Preliminary evaluation of prostate-targeted radiotherapy using (131) I-MIP-1095 in combination with radiosensitising chemotherapeutic drugs.Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics.
P2860
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P2860
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Sensitization to radiation and alkylating agents by inhibitors of poly
@nl
Sensitization to radiation and ...... DNA double-strand break repair
@en
type
label
Sensitization to radiation and alkylating agents by inhibitors of poly
@nl
Sensitization to radiation and ...... DNA double-strand break repair
@en
prefLabel
Sensitization to radiation and alkylating agents by inhibitors of poly
@nl
Sensitization to radiation and ...... DNA double-strand break repair
@en
P2093
P2860
P1476
Sensitization to radiation and ...... DNA double-strand break repair
@en
P2093
Akiko K Shibata
Anthony J Chalmers
Atsushi Shibata
Dana A Löser
Lisa J Woodbine
Penny A Jeggo
P2860
P304
P356
10.1158/1535-7163.MCT-09-1027
P577
2010-06-08T00:00:00Z