Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. - Wikidata - wikimedia - TriplyDB

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

http://www.wikidata.org/entity/Q39698930

about

Replication licensing and cancer--a fatal entanglement?Preventing re-replication of chromosomal DNA.Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Cellular checkpoint mechanisms monitoring proper initiation of DNA replication Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer.The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer.Cdk2 is required for p53-independent G2/M checkpoint control.Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.Replication licensing and the DNA damage checkpoint.The functional role of Cdc6 in S-G2/M in mammalian cells.Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.ATR signalling: more than meeting at the fork.Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest.Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling.Regulating DNA replication in eukarya.The contribution of dormant origins to genome stability: from cell biology to human genetics.Deregulated expression of Cdc6 as BCR/ABL-dependent survival factor in chronic myeloid leukemia cells.Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis.p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm.Control of Cdc6 accumulation by Cdk1 and MAPK is essential for completion of oocyte meiotic divisions in Xenopus.Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes.Significance of DNA Replication Licensing Proteins (MCM2, MCM5 and CDC6), p16 and p63 as Markers of Premalignant Lesions of the Uterine Cervix: Its Usefulness to Predict Malignant Potential Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.Ubiquitination by HUWE1 in tumorigenesis and beyond

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P2860

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

http://www.wikidata.org/entity/Q39698930

description

2003 nî lūn-bûn

@nan

2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-sg

2003年學術文章

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2003年學術文章

@zh

2003年學術文章

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name

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@en

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@nl

type

label

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@en

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@nl

prefLabel

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@en

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@nl

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P1433

The EMBO Journal

P1476

Human replication protein Cdc6 ...... echanism that implicates Chk1.

@en

P2093

Cristina Pelizon

http://www.w3.org/2001/XMLSchema#string

David Santamaria

http://www.w3.org/2001/XMLSchema#string

Lorena Clay-Farrace

http://www.w3.org/2001/XMLSchema#string

Ronald A Laskey

http://www.w3.org/2001/XMLSchema#string

P2860

The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Conserved initiator proteins in eukaryotes

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins

Identification of HsORC4, a member of the human origin of replication recognition complex

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division

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704-712

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scholarly article

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10.1093/EMBOJ/CDG046

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3

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22

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Jonathon Noe Joseph Pines

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2003-02-01T00:00:00Z

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10928036

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12554670

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140731

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