Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.
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Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent mannerStudies of retroviral infection in humanized miceValidation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretroviralsNef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.Distinct chemokine triggers and in vivo migratory paths of fluorescein dye-labeled T Lymphocytes in acutely simian immunodeficiency virus SIVmac251-infected and uninfected macaques.HIV-1 replication and pathogenesis in the human thymus.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss.The brightening future of HIV therapeutics.Host factors influencing susceptibility to HIV infection and AIDS progression.Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification RegionHuman leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2Down-regulation of cell surface CXCR4 by HIV-1HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.Viral factors in non-progression.Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms.The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Comparative genetic variability in HIV-1 subtype C nef gene in early age groups of infants.Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity.AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+ T Cells.Alkylating HIV-1 Nef - a potential way of HIV intervention.Sequence heterogeneity in human immunodeficiency virus type 1 nef in patients presenting with rapid progression and delayed progression to AIDS.Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection.Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication.
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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@en
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@nl
type
label
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@en
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@nl
prefLabel
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@en
Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@nl
P2093
P2860
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Human immunodeficiency virus t ...... ncement of viral pathogenesis.
@en
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Cheryl A Stoddart
Christopher Bare
Joseph M McCune
Mary E Moreno
Patricia A Bresnahan
Romas Geleziunas
Sharon Ferrell
Valerie Linquist-Stepps
Warner C Greene
Weiduan Xu
P2860
P304
P356
10.1128/JVI.77.3.2124-2133.2003
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P577
2003-02-01T00:00:00Z