Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal - Wikidata - wikimedia - TriplyDB

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

http://www.wikidata.org/entity/Q39700353

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Loss of pRB causes centromere dysfunction and chromosomal instability MTBP plays a crucial role in mitotic progression and chromosome segregation Chromosomal instability and cancer: a complex relationship with therapeutic potential Evolutionary determinants of cancer Twists in views on RB functions in cellular signaling, metabolism and stem cells RB1: a prototype tumor suppressor and an enigma Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis A role of WT1 in cell division and genomic stability Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo Aneuploidy underlies a multicellular phenotypic switch Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence"A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells Targeting the adaptability of heterogeneous aneuploids The causes and consequences of genetic heterogeneity in cancer evolution Cohesion fatigue induces chromatid separation in cells delayed at metaphase.MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.Chromosomal instability confers intrinsic multidrug resistance.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Genetically engineered mouse models for drug development and preclinical trials.The origins of cancer robustness and evolvability.The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation Cancer chromosomal instability: therapeutic and diagnostic challenges.Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.Biomolecular events in cancer revealed by attractor metagenes.The tumor suppressor CDKN3 controls mitosis.Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.p53: guardian of ploidy Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer Chromosomal instability as a prognostic marker in cervical cancer.Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

http://www.wikidata.org/entity/Q39700353

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2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Mad2-induced chromosome instab ...... apse after oncogene withdrawal

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Mad2-induced chromosome instab ...... pse after oncogene withdrawal.

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type

label

Mad2-induced chromosome instab ...... apse after oncogene withdrawal

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Mad2-induced chromosome instab ...... pse after oncogene withdrawal.

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prefLabel

Mad2-induced chromosome instab ...... apse after oncogene withdrawal

@en

Mad2-induced chromosome instab ...... pse after oncogene withdrawal.

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Mad2-induced chromosome instab ...... apse after oncogene withdrawal

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Juan-Manuel Schvartzman

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Nicholas D Socci

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Robert Benezra

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P2860

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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1009828897

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20173739

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2841716

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