Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
about
Environmental chemical exposures and human epigeneticsBrain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivitySynthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study groupInvestigation of Mendelian forms of obesity holds out the prospect of personalized medicine.The future of nutrition: Nutrigenomics and nutrigenetics in obesity and cardiovascular diseases.Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.A missense mutation in the rabbit melanocortin 4 receptor (MC4R) gene is associated with finishing weight in a meat rabbit line.Obesity Drug Update: The Lost Decade?Genetic variants help define the role of the MC4R C-terminus in signaling and cell surface stability.Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohortRelevance of polymorphisms in MC4R and BDNF in short normal stature
P2860
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P2860
Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Pharmacological characterizati ...... ti-related protein antagonist.
@en
Pharmacological characterizati ...... ti-related protein antagonist.
@nl
type
label
Pharmacological characterizati ...... ti-related protein antagonist.
@en
Pharmacological characterizati ...... ti-related protein antagonist.
@nl
prefLabel
Pharmacological characterizati ...... ti-related protein antagonist.
@en
Pharmacological characterizati ...... ti-related protein antagonist.
@nl
P2093
P2860
P356
P1433
P1476
Pharmacological characterizati ...... ti-related protein antagonist.
@en
P2093
Bettina Proneth
Carrie Haskell-Luevano
Marvin L Dirain
Sally A Litherland
Zhimin Xiang
P2860
P304
P356
10.1021/BI100068U
P407
P577
2010-06-01T00:00:00Z