Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. - Wikidata - wikimedia - TriplyDB

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis.

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis.

http://www.wikidata.org/entity/Q39714931

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A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6 The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6 TAK1-dependent signaling requires functional interaction with TAB2/TAB3 TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation Signaling Pathways in Osteoclast Differentiation NF-κB, the first quarter-century: remarkable progress and outstanding questions The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling Integrated analysis of gene expression profiles associated with response of platinum/paclitaxel-based treatment in epithelial ovarian cancer Pyrroloquinoline quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis.Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus.Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells.Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.Signaling to NF-kappaB: regulation by ubiquitination.CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.Osteoblast Role in Rheumatic Diseases.Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans.FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.The emerging field of osteoimmunology TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation Emerging complexity of protein ubiquitination in the NF-κB pathway.PKCβ positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3β.Cell adhesion signaling regulates RANK expression in osteoclast precursors.TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin Bone formation and resorption are both increased in experimental autoimmune arthritis.Signaling crosstalk between RANKL and interferons in osteoclast differentiation.Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease.

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P2860

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis.

http://www.wikidata.org/entity/Q39714931

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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The EMBO Journal

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Segregation of TRAF6-mediated ...... ts role in osteoclastogenesis.

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Inoue J

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Kadono Y

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Kobayashi N

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Matsumoto K

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Naito A

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Yamamoto T

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P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

RANK is essential for osteoclast and lymph node development

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

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145527

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