Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

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http://www.wikidata.org/entity/Q39729350

Q39729350

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Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options Inhibition of influenza virus replication by targeting broad host cell pathways Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic.Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion.Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.A computational method for predicting regulation of human microRNAs on the influenza virus genome.Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin.A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells.Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia Influenza A virus entry inhibitors targeting the hemagglutinin.Membrane-anchored serine proteases in health and disease.Novel hemagglutinin-based influenza virus inhibitors.IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines.Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.Antiviral strategies against influenza virus: towards new therapeutic approaches.TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.Phosphorylation of the type II transmembrane serine protease, TMPRSS13 in Hepatocyte Growth Factor Activator Inhibitor-1 and 2-mediated cell surface localization.Type II transmembrane serine proteases as potential target for anti-influenza drug discovery.In Silico Analysis of HA2/Mx Chimera Peptide for Developing an Adjuvanted Vaccine to Induce Immune Responses Against Influenza Viruses.Impact of chicken-origin cells on adaptation of a low pathogenic influenza virus.Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication.H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice.Enhanced protective efficacy of H5 subtype influenza vaccine with modification of the multibasic cleavage site of hemagglutinin in retroviral pseudotypes.Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.Influenza glycoproteins: Hemagglutinin and neuraminidase

P2860

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P2860

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

Item

http://www.wikidata.org/entity/Q39729350

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Novel type II transmembrane se ...... their multicycle replication.

@en

Novel type II transmembrane se ...... their multicycle replication.

@nl

type

Item

label

Novel type II transmembrane se ...... their multicycle replication.

@en

Novel type II transmembrane se ...... their multicycle replication.

@nl

prefLabel

Novel type II transmembrane se ...... their multicycle replication.

@en

Novel type II transmembrane se ...... their multicycle replication.

@nl

P1476

Novel type II transmembrane se ...... their multicycle replication.

@en

P2093

Etsuhisa Takahashi

http://www.w3.org/2001/XMLSchema#string

Eva Böttcher

http://www.w3.org/2001/XMLSchema#string

Hiroshi Kido

http://www.w3.org/2001/XMLSchema#string

Masanobu Ohuchi

http://www.w3.org/2001/XMLSchema#string

Mihiro Yano

http://www.w3.org/2001/XMLSchema#string

Takaaki Nakaya

http://www.w3.org/2001/XMLSchema#string

Tomo Daidoji

http://www.w3.org/2001/XMLSchema#string

Wolfgang Garten

http://www.w3.org/2001/XMLSchema#string

Yuushi Okumura

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung

Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes

Furin at the cutting edge: from protein traffic to embryogenesis and disease

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans

The proprotein convertases

P304

5089-5096

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P31

scholarly article

P356

10.1128/JVI.02605-09

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Hans-Dieter Klenk

P577

2010-03-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20219906

http://www.w3.org/2001/XMLSchema#string

P921

membrane fusion involved in viral entry into host cell

proteolysis

transmembrane protein

P932

2863848

http://www.w3.org/2001/XMLSchema#string

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

about

P2860

P2860

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

description

name

type

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932