Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
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eXamine: exploring annotated modules in networks.The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28.Constitutive β-catenin signaling by the viral chemokine receptor US28US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cellsHuman cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.Viral hijacking of G-protein-coupled-receptor signalling networks.Signaling and regulation of G-protein coupled receptors encoded by cytomegaloviruses.Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.Desensitization of herpesvirus-encoded G protein-coupled receptors.Characterization of the rhesus cytomegalovirus US28 locus.Functional analysis of human cytomegalovirus pUS28 mutants in infected cells.The chemokine receptor homologue encoded by US27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles.The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells.Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination.The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells.Receptor chimeras demonstrate that the C-terminal domain of the human cytomegalovirus US27 gene product is necessary and sufficient for intracellular receptor localization.Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28.The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src.Intracellular trafficking of the human cytomegalovirus-encoded 7-trans-membrane protein homologs pUS27 and pUL78 during viral infection: a comparative analysis.CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor.Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection.MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.US28: HCMV's Swiss Army Knife
P2860
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P2860
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
description
2003 nî lūn-bûn
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2003年の論文
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name
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@en
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@nl
type
label
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@en
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@nl
prefLabel
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@en
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@nl
P2093
P2860
P1433
P1476
Constitutive inositol phosphat ...... kine receptor homologue pUS28.
@en
P2093
Anke Lüske
Barbara Moepps
Calogero Tulone
Detlef Michel
Peter Gierschik
Rosalba Minisini
Thomas Mertens
P2860
P304
P356
10.1128/JVI.77.8.4489-4501.2003
P407
P577
2003-04-01T00:00:00Z