Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.
about
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targetsHuman small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an updateHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateTargeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer.Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy.Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancerHeat shock protein 27 phosphorylation state is associated with cancer progression.Novel drugs targeting the androgen receptor pathway in prostate cancer.OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer.Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function.Pathology-dependent effects linked to small heat shock proteins expression: an updateHeat shock protein 27 is a potential indicator for response to YangZheng XiaoJi and chemotherapy agents in cancer cells.Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors.Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules.A network-based approach for predicting Hsp27 knock-out targets in mouse skeletal muscles.Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8.Contribution of small heat shock proteins to muscle development and function.Targeting metastatic castration-resistant prostate cancer: mechanisms of progression and novel early therapeutic approaches.The role of transcription factors in prostate cancer and potential for future RNA interference therapy.Regulation of apoptosis by heat shock proteins.Targeting heat shock proteins in metastatic castration-resistant prostate cancer.Medical implications of understanding the functions of human small heat shock proteins.Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell.HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins.Heat shock protein-27 (HSP27) regulates STAT3 and eIF4G levels in first trimester human placenta.Phase I and II therapies targeting the androgen receptor for the treatment of castration resistant prostate cancer.Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitorsC-terminal heat shock protein 90 modulators produce desirable oncogenic properties.Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.Cotargeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer.Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells.The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activityElevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.Fibroblast growth factor and ornithine decarboxylase 5'UTRs enable preferential expression in human prostate cancer cells and in prostate tumors of PTEN(-/-) transgenic mice.Targeting and killing of metastatic cells in the transgenic adenocarcinoma of mouse prostate model with vesicular stomatitis virusmTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.
P2860
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P2860
Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.
description
2010 nî lūn-bûn
@nan
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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name
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@en
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@nl
type
label
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@en
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@nl
prefLabel
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@en
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@nl
P2093
P356
P1433
P1476
Heat shock protein 27 confers ...... te cancer cells through eIF4E.
@en
P2093
A De-Thonel
J L Iovanna
P2888
P304
P356
10.1038/ONC.2009.479
P407
P577
2010-01-18T00:00:00Z