Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
about
Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targetsBarium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinaseActivation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancerIntegrins in cancer: biological implications and therapeutic opportunitiesInteraction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation.CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy.SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.The role of c-Src in integrin (α6β4) dependent translational controlCritical role of Shp2 in tumor growth involving regulation of c-MycTargeting protein tyrosine phosphatases for anticancer drug discovery.Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migrationBacterial genotoxins promote inside-out integrin β1 activation, formation of focal adhesion complexes and cell spreading.An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer.Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met.αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapyA key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cellsA small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4.Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin.Netrin-1-Induced Stem Cell Bioactivity Contributes to the Regeneration of Injured Tissues via the Lipid Raft-Dependent Integrin α6β4 Signaling Pathway.Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma.Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.Genetic analyses of integrin signaling.Computational approaches for analyzing information flow in biological networks.Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer.Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress.Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4.N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.Roles of Integrin α6β4 Glycosylation in Cancer.Functional characterization of integrin alpha6beta4 adhesion interactions using soluble integrin constructs reveals the involvement of different functional domains in the beta4 subunit.Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.Intrinsic signaling functions of the beta4 integrin intracellular domain.Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses.
P2860
Q24336689-AF32C0BA-90DC-48A3-94C8-60F995D40F8AQ28477464-B8FDE7D5-C6FC-4543-A369-C409567E5D05Q28771754-4AF69451-E115-4419-950C-758D7F04994BQ29614536-CC8487A7-5806-412B-A2B0-5B943D4B4E28Q33809991-226EC172-D6B2-40FB-A5A5-3E2AA863DC5EQ34194673-CF201727-00FB-4B86-A280-E2E20E7CB4CDQ34245117-91B2FA42-3815-4A6A-A98D-1A37928EA7B3Q34290934-2B808912-4DCC-45B8-8258-34C0DB6F2850Q34386024-513FC7B6-72D5-41F1-ACD4-2C6B6DB00309Q34430926-3D24073B-500F-4052-B1BA-2B514DF7400BQ34493472-25ECA543-63BD-48FF-8409-ED1446362AF2Q34713949-44E89F81-DF1F-4C56-8FC9-C9CA3D85CDA2Q34789961-20C817CF-CA14-45FD-B16C-8E7E0AD88906Q35249284-CB56C78E-D8D7-42B0-87BC-9CBE51180593Q35601776-88A65D63-584D-49D6-8994-A5517F43C98DQ36262579-53F89B42-3B60-467C-B194-5BAD586EE89AQ36283542-FF5183B5-13CB-4D60-96B5-E26ACFDC5A72Q36545205-4A6F35F6-0FE4-4D9D-BC0C-B168671E98A3Q36783017-2C7BFB4C-8337-4BAE-9CB9-8D96405C3A3FQ36828371-ED241B5E-20ED-4110-92C6-FA24B669450CQ36982557-E3D4539B-002D-4098-B842-EAC5CD75D65FQ36995691-F1536CC3-9960-4CF4-B1BE-BABB1A354D9DQ37086011-F7202E50-4D2C-4C84-9A2B-34886A43B06CQ37164157-E69E3C31-4B10-441B-8641-49C6299F9755Q37366329-3B1F3635-7039-416D-B58C-66438F69B61DQ37435052-66F8FD5C-A4E0-43AD-971B-580A1C56215BQ37625534-952792FC-F4E4-4CC4-B0C0-C175C51C16ECQ37730158-B1163FDD-373A-44A2-8640-FE24A1BF061FQ37855339-D00E0A45-114B-4A8A-B5C4-C94C63667EE5Q38003247-16FF9CFC-324E-4E5E-B1EB-BC23F2DE3F26Q38757884-4208E358-F00D-4C71-A148-BE9C46C5CF0DQ38819327-C70CD233-F02A-4A0D-9203-ECCE65A6FB23Q38856729-BC8CF799-958B-46A3-A5CB-412E72148750Q39338632-D1845FC0-59F3-4F5E-BBF4-1E9D2E171CFFQ39377016-A17FABF9-7B0D-4613-8BC5-82EE301754FBQ39415199-4B5FAC26-725E-4730-9EAD-5E27413CEA2BQ39922248-5E3D3156-8045-4085-93E4-A61B3C755FA0Q39990859-E4180ED6-257B-4575-9878-CD56DA06730DQ40091012-3537287E-1777-4015-92A8-11A2E06855BAQ40850018-B039EC8A-DD6A-4936-87B9-991D5C212A01
P2860
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@en
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@nl
type
label
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@en
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@nl
prefLabel
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@en
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@nl
P2860
P356
P1476
Beta4 integrin activates a Shp ...... anchorage-independent growth.
@en
P2093
Livio Trusolino
P2860
P304
P356
10.1083/JCB.200605114
P407
P577
2006-12-11T00:00:00Z