Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity.
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Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cellsAn estrogen analogue and promising anticancer agent refrains from inducing morphological damage and reactive oxygen species generation in erythrocytes, fibrin and platelets: a pilot studyCompound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex IAnticancer drug 2-methoxyestradiol protects against renal ischemia/reperfusion injury by reducing inflammatory cytokines expressionStabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case studySulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells.Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell lineIn vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line.The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX ExpressionA second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model.Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovariesIn vitro assessment of a computer-designed potential anticancer agent in cervical cancer cells.2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.2-methoxyestradiol and disorders of female reproductive tissues.Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells.Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia.Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines.Role of STAT3/5 and Bcl-2/xL in 2-methoxyestradiol-induced endoreduplication of nasopharyngeal carcinoma cells.Nuclear co-localization and functional interaction of COX-2 and HIF-1α characterize bone metastasis of human breast carcinoma.Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle.Endogenous hormone 2-methoxyestradiol suppresses venous hypertension-induced angiogenesis through up- and down-regulating p53 and id-1.2-Methoxyestradiol Reverses the Pro-Carcinogenic Effect of L-Lactate in Osteosarcoma 143B Cells.The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.
P2860
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P2860
Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Structure activity analysis of ...... ive and proapoptotic activity.
@en
Structure activity analysis of ...... ive and proapoptotic activity.
@nl
type
label
Structure activity analysis of ...... ive and proapoptotic activity.
@en
Structure activity analysis of ...... ive and proapoptotic activity.
@nl
prefLabel
Structure activity analysis of ...... ive and proapoptotic activity.
@en
Structure activity analysis of ...... ive and proapoptotic activity.
@nl
P2093
P1476
Structure activity analysis of ...... ive and proapoptotic activity.
@en
P2093
Thilo Hagen
Yee Liu Chua
Yee Shin Chua
P304
P356
10.1158/1535-7163.MCT-09-1003
P577
2010-01-06T00:00:00Z