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Mechanics and contraction dynamics of single platelets and implications for clot stiffening

Mechanics and contraction dynamics of single platelets and implications for clot stiffening

http://www.wikidata.org/entity/Q39756732

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Assessing the Methodology for Calculating Platelet Contribution to Clot Strength (Platelet Component) in Thromboelastometry and Thrombelastography The platelet and the biophysical microenvironment: lessons from cellular mechanics Integration of acoustic radiation force and optical imaging for blood plasma clot stiffness measurement.Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level Rupture Forces among Human Blood Platelets at different Degrees of Activation.Physical determinants of fibrinolysis in single fibrin fibers Shear-wave elasticity measurements of three-dimensional cell cultures for mechanobiology To pull or be pulled: parsing the multiple modes of mechanotransduction.Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness.Strain tunes proteolytic degradation and diffusive transport in fibrin networks Human cartilage repair with a photoreactive adhesive-hydrogel composite.Comparison of platelet ultrastructure and elastic properties in thrombo-embolic ischemic stroke and smoking using atomic force and scanning electron microscopy.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia Single-molecule force spectroscopy applied to heparin-induced thrombocytopenia.An AFM-based stiffness clamp for dynamic control of rigidity Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression Structural basis for the nonlinear mechanics of fibrin networks under compression.Tensional homeostasis in single fibroblasts.Contractile equilibration of single cells to step changes in extracellular stiffness Emerging microengineered tools for functional analysis and phenotyping of blood cells.Elastic behavior and platelet retraction in low- and high-density fibrin gels.Mechanobiology of platelets: techniques to study the role of fluid flow and platelet retraction forces at the micro- and nano-scale.Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.Platelet hyperactivity and fibrin clot structure in transient ischemic attack individuals in the presence of metabolic syndrome: a microscopy and thromboelastography study.Blood and immune cell engineering: Cytoskeletal contractility and nuclear rheology impact cell lineage and localization: Biophysical regulation of hematopoietic differentiation and trafficking.FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction Non-affinity factors modulating vascular targeting of nano- and microcarriers Fiber networks amplify active stress.State of the art in platelet function testing.Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.Biomechanics of haemostasis and thrombosis in health and disease: from the macro- to molecular scale Cells actively stiffen fibrin networks by generating contractile stress.Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.Multiscale modeling of platelet adhesion and thrombus growth.Rho GTPases in platelet function Systems biology of platelet-vessel wall interactions.Basic mechanisms and regulation of fibrinolysis.

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Mechanics and contraction dynamics of single platelets and implications for clot stiffening

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2010 nî lūn-bûn

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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name

Mechanics and contraction dyna ...... plications for clot stiffening

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Mechanics and contraction dyna ...... lications for clot stiffening.

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Mechanics and contraction dyna ...... plications for clot stiffening

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Mechanics and contraction dyna ...... lications for clot stiffening.

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Mechanics and contraction dyna ...... plications for clot stiffening

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Mechanics and contraction dyna ...... lications for clot stiffening.

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Mechanics and contraction dyna ...... plications for clot stiffening

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Ailey Crow

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Ashley Kita

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Kevin D Webster

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Ovijit Chaudhuri

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Wilbur A Lam

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P2860

The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia

Differential force microscope for long time-scale biophysical measurements.

Fibrin fibers have extraordinary extensibility and elasticity.

Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells.

Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water.

Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects.

Structural origins of fibrin clot rheology

Efficiency of platelet adhesion to fibrinogen depends on both cell activation and flow

Single myosin molecule mechanics: piconewton forces and nanometre steps.

Platelet interaction with polymerizing fibrin.

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10.1038/NMAT2903

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