Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
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Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cellsStable tumor vessel normalization with pO₂ increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment.Renal tubular angiogenic dysregulation in anti-Thy1.1 glomerulonephritis.Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cellsOverexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survivalProlyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells.Effect of stable transfection with PHD3 on growth and proliferation of HepG2 cells in vitro and in vivo.Suppression of glioma progression by Egln3mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen.Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells.Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxiaThe developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view.A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitinationFunction and expression of prolyl hydroxylase 3 in cancers.Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.Potential regulation of glioma through the induction of apoptosis signaling via Egl-9 family hypoxia-inducible factor 3Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.PHD2 in tumour angiogenesis.Glioblastoma angiogenesis: VEGF resistance solutions and new strategies based on molecular mechanisms of tumor vessel formation.HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression.Genetic modification of hypoxia signaling in animal models and its effect on cancer.MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia.Hypoxia inducible factors in hepatocellular carcinomaImplications of Oxygen Homeostasis for Tumor Biology and Treatment.PHD3 regulates EGFR internalization and signalling in tumours.New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-αHIF-mediated innate immune responses: cell signaling and therapeutic implications.Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges.Effect of silencing HIF-1α on proliferation, invasion and migration of glioblastoma U87 cells.An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α.Hypoxia-Inducible Factor α and Hif-prolyl Hydroxylase Characterization and Gene Expression in Short-Time Air-Exposed Mytilus galloprovincialis.Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke.
P2860
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P2860
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@en
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@nl
type
label
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@en
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@nl
prefLabel
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@en
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@nl
P2093
P1433
P1476
Prolyl hydroxylases 2 and 3 ac ...... of hypoxia-inducible factors.
@en
P2093
Anne-Theres Henze
Ingo Flamme
Jacques Pouyseggur
Johanna Riedel
Julia Wenner
Karl H Plate
Tanja Diem
Till Acker
P304
P356
10.1158/0008-5472.CAN-09-1876
P407
P577
2009-12-22T00:00:00Z