The multi-domain protein Np95 connects DNA methylation and histone modification. - Wikidata - wikimedia - TriplyDB

The multi-domain protein Np95 connects DNA methylation and histone modification.

The multi-domain protein Np95 connects DNA methylation and histone modification.

http://www.wikidata.org/entity/Q39760453

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Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1 Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene.Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease Epigenetic Alterations in Alzheimer's Disease DNA methylation pathways and their crosstalk with histone methylation Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2 Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1 Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules The cell proliferation antigen Ki-67 organises heterochromatin Recognition of methylated DNA through methyl-CpG binding domain proteins.Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.Introduction--Epiphanies in epigenetics.Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals.Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.Effect of estrogen receptor α binding on functional DNA methylation in breast cancer.UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation Identification and functional analysis of 9p24 amplified genes in human breast cancer.Dynamic instability of genomic methylation patterns in pluripotent stem cells.Citrullination of histone H3 interferes with HP1-mediated transcriptional repression.DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Uhrf2 is important for DNA damage response in vascular smooth muscle cells.Understanding the relationship between DNA methylation and histone lysine methylation.H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing.Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome.UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation Elevated expression of UHRF1 predicts unfavorable prognosis for patients with hepatocellular carcinoma.Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration Digging deep into "dirty" drugs - modulation of the methylation machinery.Research resource: identification of novel coregulators specific for thyroid hormone receptor-β2.Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

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The multi-domain protein Np95 connects DNA methylation and histone modification.

http://www.wikidata.org/entity/Q39760453

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

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2009年學術文章

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name

The multi-domain protein Np95 connects DNA methylation and histone modification.

@en

The multi-domain protein Np95 connects DNA methylation and histone modification.

@nl

type

label

The multi-domain protein Np95 connects DNA methylation and histone modification.

@en

The multi-domain protein Np95 connects DNA methylation and histone modification.

@nl

prefLabel

The multi-domain protein Np95 connects DNA methylation and histone modification.

@en

The multi-domain protein Np95 connects DNA methylation and histone modification.

@nl

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P1433

Nucleic Acids Research

P1476

The multi-domain protein Np95 connects DNA methylation and histone modification

@en

P2093

Andrea Rottach

http://www.w3.org/2001/XMLSchema#string

Carina Frauer

http://www.w3.org/2001/XMLSchema#string

Garwin Pichler

http://www.w3.org/2001/XMLSchema#string

Heinrich Leonhardt

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Ian Marc Bonapace

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P2860

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

DNA methylation patterns and epigenetic memory

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation

ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

Replication-independent chromatin loading of Dnmt1 during G2 and M phases

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Np95 is a histone-binding protein endowed with ubiquitin ligase activity

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1796-1804

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scholarly article

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10.1093/NAR/GKP1152

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6

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38

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2009-12-21T00:00:00Z

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40757109

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20026581

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DNA methylation

P932

2847221

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