Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
about
Transcription factors in late megakaryopoiesis and related platelet disordersSignal transduction in the chronic leukemias: implications for targeted therapiesNovel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1Pathophysiology and therapeutic options in primary immune thrombocytopenia.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.Low frequency of c-MPL gene mutations in Iranian patients with Philadelphia-negative myeloproliferative disorders.His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin ReceptorDifferent mutations of the human c-mpl gene indicate distinct haematopoietic diseasesTryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasmsFLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.Advances in understanding the pathogenesis of familial thrombocythaemia.Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations.Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK.A link between the driver mutations and dysregulated apoptosis in BCR-ABL1 negative myeloproliferative neoplasms.Molecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A ReviewPhosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling.Epigenetics in Myeloproliferative Neoplasms.Orientation-specific signalling by thrombopoietin receptor dimers.A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.Frequencies, clinical characteristics, and outcome of somatic CALR mutations in JAK2-unmutated essential thrombocythemia.Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.Classical Philadelphia-negative myeloproliferative neoplasms: focus on mutations and JAK2 inhibitors
P2860
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P2860
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@en
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@nl
type
label
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@en
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@nl
prefLabel
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@en
Induction of myeloproliferativ ...... tyrosine 112 of the receptor.
@nl
P2093
P50
P1433
P1476
Induction of myeloproliferativ ...... c tyrosine 112 of the receptor
@en
P2093
Christian Pecquet
Hélène A Poirel
Jean-Marie Scheiff
Joanne Van Hees
Judith Staerk
Kimberly A Lee
Roberto D Polakiewicz
Stéphane Giraudier
Valerie Goss
P304
P356
10.1182/BLOOD-2008-10-183558
P407
P577
2009-12-08T00:00:00Z