Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
about
Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapyGSK-3 as potential target for therapeutic intervention in cancerInTERTesting association between telomerase, mTOR and phytochemicalsMaintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth.Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancerAberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy.The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells.Resveratrol plays dual roles in pancreatic cancer cells.Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer.Aspartate β-hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma.Metabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: implications for new therapeutic strategies.Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-cateninGlycogen synthase kinase 3 beta: can it be a target for oral cancer.Combining immunotherapy and targeted therapies in cancer treatment.The role of glycogen synthase kinase 3-β in immunity and cell cycle: implications in esophageal cancer.Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb.Inhibition of glycogen synthase kinase 3 beta (GSK3β) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity.Glycogen synthase kinase-3β inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth.Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner.Nuclear expression of glycogen synthase kinase-3β and lack of membranous β-catenin is correlated with poor survival in colon cancer.Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation.Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo.PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling.GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway.Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.Engrailed-2 promoter hyper-methylation is associated with its downregulation in clear cell renal cell carcinoma.GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents.Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction.Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma.Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer.Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy.Glycogen synthase kinase 3 regulates IL-1β mediated iNOS expression in hepatocytes by down-regulating c-Jun.
P2860
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P2860
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@en
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@nl
type
label
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@en
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@nl
prefLabel
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@en
Deregulated GSK3{beta} sustain ...... transcriptase and telomerase.
@nl
P2093
P1476
Deregulated GSK3{beta} sustain ...... e transcriptase and telomerase
@en
P2093
Abbas Shakoori
Kazuyuki Kawakami
Kenji Yokoi
Mingji Jin
Satoru Kyo
Takeo Shimasaki
Toshinari Minamoto
Yoshiharu Motoo
P304
P356
10.1158/1078-0432.CCR-09-0973
P407
P577
2009-11-10T00:00:00Z