Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry.
about
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domainThe tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoproteinPhosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.Commonly used tag combinations for tandem affinity purification.Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastomaStudies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lympNovel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation.
P2860
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P2860
Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
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name
Functional characterization of ...... omatography-mass spectrometry.
@en
Functional characterization of the kinase activation loop in nucleophosmin
@nl
type
label
Functional characterization of ...... omatography-mass spectrometry.
@en
Functional characterization of the kinase activation loop in nucleophosmin
@nl
prefLabel
Functional characterization of ...... omatography-mass spectrometry.
@en
Functional characterization of the kinase activation loop in nucleophosmin
@nl
P2093
P2860
P356
P1476
Functional characterization of ...... romatography-mass spectrometry
@en
P2093
P2860
P304
P356
10.1074/JBC.M109.059758
P407
P50
P577
2009-11-02T00:00:00Z