Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression.

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A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart.

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Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression.

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2015 nî lūn-bûn

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Cardiac AAV9 Gene Delivery Str ...... m Iodide Symporter Expression.

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Cardiac AAV9 Gene Delivery Str ...... m Iodide Symporter Expression.

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Cardiac AAV9 Gene Delivery Str ...... um Iodide Symporter Expression

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Atta Behfar

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David Kaye

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Gurpreet Sandhu

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Jimmy Storlie

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Linh Pham

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Lorna Bowen

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Margaret Redfield

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Michael O'Connor

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Ozgur Ogut

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P2860

The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies

Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model

Fasting increases the in vivo gene delivery of AAV vectors.

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure.

Normalisation to blood activity is required for the accurate quantification of Na/I symporter ectopic expression by SPECT/CT in individual subjects.

Optimized delivery system achieves enhanced endomyocardial stem cell retention.

Rescuing the failing heart by targeted gene transfer

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction.

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10.1038/MT.2015.78

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Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression.

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P2860

P2860

Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression.

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