Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1 - Wikidata - wikimedia - TriplyDB

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

http://www.wikidata.org/entity/Q39790953

about

Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses Vav family exchange factors: an integrated regulatory and functional view An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.Two types of precursor cells in a multipotential hematopoietic cell line.Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.Ras/MAPK signaling from endomembranes Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q.Structural flexibility of small GTPases. Can it explain their functional versatility?Lymphocyte calcium signaling from membrane to nucleus.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T cells.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure.Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.Central role of PI3K-SYK interaction in fibrinogen-induced lamellipodia and filopodia formation in platelets.Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling.Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

P2860

Q24319008-B55893CE-8C08-454A-A09E-C6B0DC13185D Q24681250-286A169F-8BB2-494B-B75D-C4A33D37ABC2 Q27026905-73756B87-DB46-4E2F-AAB6-D54103EB5A4B Q30159794-AAA52654-6EE7-40AE-90C7-E6A96662C6BE Q30539004-BB015320-1717-49E3-B267-F00EC4E48CA6 Q33322525-D6D98578-EEB7-4675-B25E-B6B78276C3A8 Q34234814-15039ADF-B1A6-44ED-B2BF-140D6439DD8A Q34360144-5972FA5A-D281-4D75-BEE7-F26288178E9C Q34413566-EAB67915-AC79-4F69-99CC-3C66DBAEBCEE Q34565554-93FA8FDD-12E6-41D4-B7B5-BCF9476D8490 Q34651249-CD1090DD-D5B7-4547-B2E6-9062EB8DD3D8 Q34752626-C7867D2E-5F27-4338-9026-0C3E528C21A9 Q35083742-4AC58D09-C355-471A-B245-3DA3DE9DEAE2 Q35580883-4B6D383C-98E0-40FD-9777-017C70A0C046 Q35669628-13B1DF79-762E-4CAF-AED6-3F90E4B80AD9 Q35944673-6662AA56-9416-47B7-8B73-6CD419249C44 Q36011162-CF616E8B-BDD7-4DB4-AB41-24E8175BBB6E Q36343541-9264C11A-07BC-4002-8373-997659D976B9 Q36398735-D2377EC5-1405-4639-8C7F-1B36FD3E199B Q36514283-F16D4670-D93B-4938-BC02-DFB003637B83 Q36786805-73476848-C739-49C7-94DC-555CFE38779E Q36978232-8DA2F73C-52DB-4830-BBED-9A7BF56C68B2 Q37431056-9D6305E8-D02A-4552-B3FF-0FA7283CB360 Q38345428-304ED195-E084-4349-AA94-FBB27DAB7583 Q38811919-4F3840C9-0052-4F18-9976-56D39C825F85 Q39923203-E28C9F1C-8688-45BD-A91D-D561B19D7BFA Q40128306-198B6D59-F30E-4512-BE50-745D82E13124 Q40540260-B28D3C46-984B-415A-BE10-E1355E8F6206 Q40588937-63FB1AC6-3BB0-4FA4-B243-697674D495B3 Q41779379-31FB09A2-01DB-484E-8F4F-F21FC47E894B Q42229532-56778F8F-12A6-41A0-AF6D-9C93B779BDD6 Q42414565-96197877-D566-4E7E-83EA-4B88DFEE6261 Q42798741-4D0CC7A4-4466-4F0C-93A2-52E53295DCAB Q44779423-2435C342-678A-43CC-A29C-44F8AA0984C2 Q46832394-52467161-389E-41D0-A5F2-C6667CDF95B7 Q46874924-10B85564-FF96-4F46-A668-65846D883141 Q48152427-9F5B3C31-B614-4C18-BD31-55BB37ABA85C Q57980185-8CAD562C-D506-4D5D-B3C1-F8B96F04F98D

P2860

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

http://www.wikidata.org/entity/Q39790953

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

2003年论文

@zh

2003年论文

@zh-cn

name

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

@en

Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.

@nl

type

label

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

@en

Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.

@nl

prefLabel

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

@en

Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.

@nl

P1433

Q39790953-EEA7E7BB-1780-4CBA-A226-7287D46BFC45

P1476

Q39790953-91D4ACA5-78A5-4AD3-9751-36693D80DDE7

P2093

Q39790953-875DCBE4-8C0C-447B-AF0E-D5C91ECAED71

Q39790953-B7259B9A-89EA-4B8A-A8E3-D4B058746712

P2860

Q39790953-02B2FD30-67B6-4685-90AB-0710E971D0F3

Q39790953-12E4AD22-87A8-46AB-92D4-B49254A3035D

Q39790953-17AC7C55-289C-4E83-B7B2-6129AFA07734

Q39790953-1975CA72-37E2-450F-8B0C-98F5C02F05F4

Q39790953-20AC0473-0460-44DE-ABDE-6FD13452E9EA

Q39790953-23653761-822B-4117-BC87-133DAB46A248

Q39790953-2C25A361-EF23-4400-94D3-00BC7E104661

Q39790953-32AFC13F-B007-48EB-811A-E053D674832C

Q39790953-3AE81374-F4C1-4E45-B69B-D1D4F3EE3658

Q39790953-3B34C87E-4BDD-4185-B336-2A9BFF2160FB

P304

Q39790953-515BEE53-8F85-4763-B592-75CB95E7E236

P31

Q39790953-2D80E1D6-4137-460A-B098-E2CE1863C78D

P356

Q39790953-494842D6-A019-41D2-9B91-19A2DB6FC597

P407

Q39790953-E952C4E9-CCFA-43BE-8E80-65E02B5435AF

P433

Q39790953-2F82AD0B-14ED-4AFB-9AF4-61BEAC037BCE

P478

Q39790953-BB4C62B4-BEC5-46ED-B2A5-48A81C5C6922

P50

Q39790953-3068C10F-2C01-4283-A924-AE67B5575393

Q39790953-9897387B-6D47-4D36-8DCF-B456E8B9B622

Q39790953-C4D90BFD-967F-405F-9163-E95AADD5011E

P577

Q39790953-63AAFA01-BC96-4F7C-96A4-F5D204455DF9

P5875

Q39790953-7083FD40-2739-4692-A6A1-E4EB792DDEDD

P698

Q39790953-BE131AFC-3683-4CE9-AFF1-23C0F05CFC4D

P932

Q39790953-14193F29-C3F9-4C98-BF84-DDF445908E72

P356

P1433

The EMBO Journal

P1476

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

@en

P2093

José L Zugaza

http://www.w3.org/2001/XMLSchema#string

María J Caloca

http://www.w3.org/2001/XMLSchema#string

P2860

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

Regulatory and signaling properties of the Vav family

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Deficiency of small GTPase Rac2 affects T cell activation

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

P304

3326-3336

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/EMBOJ/CDG316

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P50

Xosé R. Bustelo

David Matallanas

P577

2003-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6690072

http://www.w3.org/2001/XMLSchema#string

P698

12839994

http://www.w3.org/2001/XMLSchema#string

P932

165641

http://www.w3.org/2001/XMLSchema#string