Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
about
Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signalingRasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responsesVav family exchange factors: an integrated regulatory and functional viewAn active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligandCoactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.Two types of precursor cells in a multipotential hematopoietic cell line.Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.Ras/MAPK signaling from endomembranesPhylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytesPhosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsGuanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathwaysOverexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q.Structural flexibility of small GTPases. Can it explain their functional versatility?Lymphocyte calcium signaling from membrane to nucleus.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T cells.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure.Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.Central role of PI3K-SYK interaction in fibrinogen-induced lamellipodia and filopodia formation in platelets.Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signalingF-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling.Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1
P2860
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P2860
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
@en
Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.
@nl
type
label
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
@en
Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.
@nl
prefLabel
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
@en
Vav mediates Ras stimulation b ...... /GTP exchange factor Ras GRP1.
@nl
P2860
P50
P356
P1433
P1476
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
@en
P2093
José L Zugaza
María J Caloca
P2860
P304
P356
10.1093/EMBOJ/CDG316
P407
P577
2003-07-01T00:00:00Z