Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
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The role of HDAC6 in cancerFam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiationMice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortionA novel GRK2/HDAC6 interaction modulates cell spreading and motilityThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationClass IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactinThe ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronsStructural insights into HDAC6 tubulin deacetylation and its selective inhibitionSirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosisHDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesSeptins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivoΑ-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesionInvolvement of the Rho-mDia1 pathway in the regulation of Golgi complex architecture and dynamicsTubulin acetyltransferase αTAT1 destabilizes microtubules independently of its acetylation activity.Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assemblyAltered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylationPost-translational modifications of microtubules.Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions.Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2.Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules.Tubulin acetylation: responsible enzymes, biological functions and human diseases.Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis.SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.Management of cytoskeleton architecture by molecular chaperones and immunophilins.Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neuronsGenetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organizationHistone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometryBoth HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.Microtubule modifications and stability are altered by cilia perturbation and in cystic kidney disease.
P2860
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P2860
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@en
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@nl
type
label
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@en
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@nl
prefLabel
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@en
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@nl
P2093
P356
P1476
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
@en
P2093
Alexander Bershadsky
Christoph Ballestrem
Letizia Carramusa
Ralph Mazitschek
Saadi Khochbin
Yuliya Zilberman
P304
P356
10.1242/JCS.046813
P407
P577
2009-09-08T00:00:00Z