Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
about
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophagesAn aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes.A novel class of small molecule inhibitors of HDAC6.Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors.SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscleTargeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity.Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia.Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Selective class IIa HDAC inhibitors: myth or reality.Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups.A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.
P2860
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P2860
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
description
2009 nî lūn-bûn
@nan
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
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name
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@en
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@nl
type
label
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@en
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@nl
prefLabel
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@en
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@nl
P2093
P1476
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
@en
P2093
Amal Wahhab
David V Smil
Jeffrey M Besterman
Jubrail Rahil
Pierre Tessier
Robert Déziel
Silvana Leit
P304
P356
10.1016/J.BMCL.2009.08.010
P407
P577
2009-08-07T00:00:00Z