Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
about
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesisPhosphoinositides: Key modulators of energy metabolismA Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug DiscoveryTks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cellsScreening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamicsSeizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism.Discovery and development of small molecule SHIP phosphatase modulators.PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.SHIP2 and its involvement in various diseases.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.The chemical biology of phosphoinositide 3-kinases.SHIP2: Structure, Function and Inhibition.INPPL1 gene mutations in opsismodysplasiaInhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosisThe inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.Biochemical and cellular properties of insulin receptor signalling.Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation.Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.
P2860
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P2860
Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@en
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@nl
type
label
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@en
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@nl
prefLabel
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@en
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@nl
P2093
P2860
P1476
Discovery and functional chara ...... racellular phosphatase, SHIP2.
@en
P2093
T Shimokawa
T Yamamoto
P2860
P304
P356
10.1111/J.1476-5381.2009.00358.X
P407
P577
2009-08-19T00:00:00Z