Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.
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Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humansTherapeutic Potential of Targeting the Ghrelin Pathway.Integrating GHS into the Ghrelin System.G Protein and β-arrestin signaling bias at the ghrelin receptor.Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice.Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelinAgonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor SignalingA Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Superagonism at G protein-coupled receptors and beyond.Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand.High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs.MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.
P2860
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P2860
Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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name
Growth hormone secretagogues a ...... vation of the G protein Galpha
@nl
Growth hormone secretagogues a ...... a(o1) by the Ghrelin receptor.
@en
type
label
Growth hormone secretagogues a ...... vation of the G protein Galpha
@nl
Growth hormone secretagogues a ...... a(o1) by the Ghrelin receptor.
@en
prefLabel
Growth hormone secretagogues a ...... vation of the G protein Galpha
@nl
Growth hormone secretagogues a ...... a(o1) by the Ghrelin receptor.
@en
P2093
P2860
P356
P1476
Growth hormone secretagogues a ...... a(o1) by the Ghrelin receptor.
@en
P2093
Christopher J Langmead
Graeme Milligan
Kirstie A Bennett
P2860
P304
P356
10.1124/MOL.109.056101
P577
2009-07-22T00:00:00Z