Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.
about
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoterReceptor-mediated folate accumulation is regulated by the cellular folate contentFunctional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair associationStable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasisStructure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritisEnhancing the therapeutic efficacy of adenovirus in combination with biomaterials.Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium.The effect of folate on the methotrexate/indomethacin interaction in a murine cancer cell line.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Complementation of a methotrexate uptake defect in Chinese hamster ovary cells by DNA-mediated gene transferCharacterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods.The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro.Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation.Mutations in the reduced-folate carrier affect protein localization and stability.Interaction between methotrexate and indomethacin on a human normal haemopoietic cell lineImpairment of methotrexate transport is common in osteosarcoma tumor samplesEndocytosis of GPI-linked membrane folate receptor-alphaTranscript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons.
P2860
Q24534785-B0580EA2-FBF5-4911-836A-832C8A359556Q24630200-99993CF7-FE12-437C-A0FB-BAADF3D53E06Q28346424-3F942EA2-F5FF-46CC-A47F-51EE267AEA4FQ33894749-34ADE2C6-07D9-4628-833D-279B8D89EB85Q34656357-233D7811-2D4D-490F-8997-0612B13E9D84Q34657202-8DFEACDF-094E-49EA-9BEF-461FE57AC545Q35555441-90DFE928-B870-4AE8-B372-29F57C8D97B8Q35624010-F923A08C-F7B1-4D97-9F36-B632C0AF16ACQ35821630-79EB5D5A-E437-438E-9EFC-B0400CB47D59Q35872985-34C2DB24-BE06-4B93-B139-01A7D943D21FQ36153041-F1104FB9-C7AB-49BD-AEB4-66E3F4A92C39Q36764563-44913173-E918-49B6-8762-06AD93135C8FQ38354623-246E4580-09D1-4992-A1F8-D0B284D89583Q40340486-390291F1-0561-41D6-9894-8DAF2099D845Q40380191-E8468AF5-08F3-4F27-87BB-7819925B3060Q40891908-07AB8F3B-E30F-4DF5-A3A8-3D7EC809F6CCQ41376813-3FBC11E6-CAF0-400B-BE76-58AF1D376B10Q41848884-5FE5484D-CAA7-412D-BCD5-F358A1AE96C2Q42771907-8D5C44BF-9052-424F-B8C4-B824595F6E1FQ42990934-CB541162-45AE-4B2A-B240-9B4ACFF40E00
P2860
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Obligate genetic expression in ...... roved therapy of human cancer.
@en
Obligate genetic expression in ...... roved therapy of human cancer.
@nl
type
label
Obligate genetic expression in ...... roved therapy of human cancer.
@en
Obligate genetic expression in ...... roved therapy of human cancer.
@nl
prefLabel
Obligate genetic expression in ...... roved therapy of human cancer.
@en
Obligate genetic expression in ...... roved therapy of human cancer.
@nl
P1433
P1476
Obligate genetic expression in ...... roved therapy of human cancer.
@en
P2093
Sirotnak FM
P304
P407
P577
1985-09-01T00:00:00Z