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Synergistic drug combinations tend to improve therapeutically relevant selectivity

Synergistic drug combinations tend to improve therapeutically relevant selectivity

http://www.wikidata.org/entity/Q39828335

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When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.Advances in drug delivery system for platinum agents based combination therapy Synthetic biology for pharmaceutical drug discovery What is synergy? The Saariselkä agreement revisited Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs Quantitative phenotypic and pathway profiling guides rational drug combination strategies Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors.Synergy Maps: exploring compound combinations using network-based visualization Biomolecular Network-Based Synergistic Drug Combination Discovery Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats Drug inhibition profile prediction for NFκB pathway in multiple myeloma Prediction of drug combinations by integrating molecular and pharmacological data Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways Searching for synergies: matrix algebraic approaches for efficient pair screening Systems modeling of anti-apoptotic pathways in prostate cancer: psychological stress triggers a synergism pattern switch in drug combination therapy A network inference method for large-scale unsupervised identification of novel drug-drug interactions The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicity ASDCD: antifungal synergistic drug combination database Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia Synergistic and antagonistic drug combinations depend on network topology Synergistic interaction between selective drugs in cell populations models Codelivery of chemotherapeutics via crosslinked multilamellar liposomal vesicles to overcome multidrug resistance in tumor Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling Combinations of Kinase Inhibitors Protecting Myoblasts against Hypoxia A Network-Based Target Overlap Score for Characterizing Drug Combinations: High Correlation with Cancer Clinical Trial Results The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis From single target to multitarget/network therapeutics in Alzheimer's therapy Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.Polymeric Nanostructures for Imaging and Therapy Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.Systematic identification of synergistic drug pairs targeting HIV

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P2860

Synergistic drug combinations tend to improve therapeutically relevant selectivity

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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Synergistic drug combinations tend to improve therapeutically relevant selectivity

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Synergistic drug combinations tend to improve therapeutically relevant selectivity.

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Synergistic drug combinations tend to improve therapeutically relevant selectivity

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Synergistic drug combinations tend to improve therapeutically relevant selectivity.

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Synergistic drug combinations tend to improve therapeutically relevant selectivity

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Synergistic drug combinations tend to improve therapeutically relevant selectivity.

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Nature Biotechnology

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Synergistic drug combinations tend to improve therapeutically relevant selectivity

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Adrian M Heilbut

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Alexis A Borisy

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Andrew S Krueger

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E Roydon Price

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Glenn F Short

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Grant R Zimmermann

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Jane E Staunton

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Joseph Lehár

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Lisa M Johansen

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Margaret S Lee

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P2860

Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions

A gene atlas of the mouse and human protein-encoding transcriptomes

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Global mapping of the yeast genetic interaction network.

The concept of synthetic lethality in the context of anticancer therapy

Network pharmacology: the next paradigm in drug discovery

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data

An integrated platform of genomic assays reveals small-molecule bioactivities.

Principles for the buffering of genetic variation.

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10.1038/NBT.1549

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7

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27

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19581876

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