Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
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The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerusTwo sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerusSynergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces speciesbeta-Lactam synthetase: a new biosynthetic enzymeGenome-minimized Streptomyces host for the heterologous expression of secondary metabolism.Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerusEnzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerusApplications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus.A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus.ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus.Transcriptional Responses Associated with Virulence and Defence in the Interaction between Heterobasidion annosum s.s. and Norway SpruceClavulanic acid biosynthesis and genetic manipulation for its overproduction.Biosynthesis of clavam metabolites.Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement.Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus.Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerusExpression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.pcd mutants of Streptomyces clavuligerus still produce cephamycin C.Carboxyethylarginine synthase genes show complex cross-regulation in Streptomyces clavuligerus.A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus.
P2860
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P2860
Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
description
1995 nî lūn-bûn
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1995年の論文
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年學術文章
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name
Functional analysis of the gen ...... s in Streptomyces clavuligerus
@en
Functional analysis of the gen ...... in Streptomyces clavuligerus.
@nl
type
label
Functional analysis of the gen ...... s in Streptomyces clavuligerus
@en
Functional analysis of the gen ...... in Streptomyces clavuligerus.
@nl
prefLabel
Functional analysis of the gen ...... s in Streptomyces clavuligerus
@en
Functional analysis of the gen ...... in Streptomyces clavuligerus.
@nl
P2860
P1476
Functional analysis of the gen ...... s in Streptomyces clavuligerus
@en
P2093
Paradkar AS
P2860
P304
P356
10.1128/JB.177.5.1307-1314.1995
P577
1995-03-01T00:00:00Z