A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells

about

Novel investigational drugs active as single agents in multiple myeloma.Melflufen - a peptidase-potentiated alkylating agent in clinical trials.Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.

P2860

Q38690290-9511F307-592A-4A0C-A3C6-32B59964519C Q42371678-FF1E1FD5-0DF1-440E-9E3B-E7644A937452 Q50233866-EB5AA13A-921C-4E03-AD9A-97DA9E5DA848

P2860

A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells

Item

http://www.wikidata.org/entity/Q39836136

description

2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年学术文章

@wuu

2016年学术文章

@zh-cn

2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

@zh-sg

2016年學術文章

@yue

2016年學術文章

@zh

2016年學術文章

@zh-hant

name

A novel alkylating agent Melfl ...... city in multiple myeloma cells

@en

A novel alkylating agent Melfl ...... ity in multiple myeloma cells.

@nl

type

Item

label

A novel alkylating agent Melfl ...... city in multiple myeloma cells

@en

A novel alkylating agent Melfl ...... ity in multiple myeloma cells.

@nl

prefLabel

A novel alkylating agent Melfl ...... city in multiple myeloma cells

@en

A novel alkylating agent Melfl ...... ity in multiple myeloma cells.

@nl

P1476

A novel alkylating agent Melfl ...... city in multiple myeloma cells

@en

P2093

Arghya Ray

http://www.w3.org/2001/XMLSchema#string

Deepika S Das

http://www.w3.org/2001/XMLSchema#string

Dharminder Chauhan

http://www.w3.org/2001/XMLSchema#string

Durgadevi Ravillah

http://www.w3.org/2001/XMLSchema#string

Eva Nordström

http://www.w3.org/2001/XMLSchema#string

Joachim Gullbo

http://www.w3.org/2001/XMLSchema#string

Yan Song

http://www.w3.org/2001/XMLSchema#string

P2860

Ku, a DNA repair protein with multiple cellular functions?

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial

An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells

In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells.

Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan.

Aminopeptidase N (CD13) as a target for cancer chemotherapy.

High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma.

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo.

P304

397-409

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/BJH.14065

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

174

http://www.w3.org/2001/XMLSchema#string

P50

Kenneth C Anderson

Paul G Richardson

P577

2016-04-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27098276

http://www.w3.org/2001/XMLSchema#string

P921

cytotoxicity

DNA damage

P932

4961600

http://www.w3.org/2001/XMLSchema#string

A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells

about

P2860

P2860

A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932