Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520
about
dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptomeGenetic locus required for antigenic maturation of Rhizobium etli CE3 lipopolysaccharide.Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies.FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensisBiosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Molecular characterization of a novel temperate sinorhizobium bacteriophage, ФLM21, encoding DNA methyltransferase with CcrM-like specificity.Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BPComparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil.Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects.Improvement of FK506 production by synthetic biology approaches.FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.Characterization of Sinorhizobium sp. LM21 Prophages and Virus-Encoded DNA Methyltransferases in the Light of Comparative Genomic Analyses of the Sinorhizobial Virome.Origin of the allyl group in FK506 biosynthesis.AglP is a S-adenosyl-L-methionine-dependent methyltransferase that participates in the N-glycosylation pathway of Haloferax volcanii.A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.Evolution of copper arsenate resistance for enhanced enargite bioleaching using the extreme thermoacidophile Metallosphaera sedula.FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256.Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.
P2860
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P2860
Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Characterization of methyltran ...... nosuppressants FK506 and FK520
@en
Characterization of methyltran ...... osuppressants FK506 and FK520.
@nl
type
label
Characterization of methyltran ...... nosuppressants FK506 and FK520
@en
Characterization of methyltran ...... osuppressants FK506 and FK520.
@nl
prefLabel
Characterization of methyltran ...... nosuppressants FK506 and FK520
@en
Characterization of methyltran ...... osuppressants FK506 and FK520.
@nl
P2093
P2860
P1476
Characterization of methyltran ...... nosuppressants FK506 and FK520
@en
P2093
B H Arison
H Motamedi
R R Miller
S L Streicher
P2860
P304
P356
10.1128/JB.178.17.5243-5248.1996
P577
1996-09-01T00:00:00Z