Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis.
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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoG2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarizationPhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseGSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synucleinThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseasePost translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Cellular processing of myocilin.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivoTargeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in MouseCharacterization of kinases involved in the phosphorylation of aggregated α-synuclein.Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.Role of Ser129 phosphorylation of α-synuclein in melanoma cellsInfluence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.Pharmacological therapy in Parkinson's disease: focus on neuroprotection.Oxidative protein damage and the proteasome.Parkinson's disease dementia and potential therapeutic strategies.Mitochondrial contribution to Parkinson's disease pathogenesis.Mitochondrial pathology in Parkinson's disease.Adjunctive therapy in Parkinson's disease: the role of rasagiline.α-Synuclein and neuronal cell death.Protein phosphorylation in neurodegeneration: friend or foe?Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Targeted suppression of chaperone-mediated autophagy by miR-320a promotes α-synuclein aggregation.Pramipexole reduces phosphorylation of α-synuclein at serine-129.Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC.Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.White matter hypoperfusion and damage in dementia: post-mortem assessment.Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease.α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.(-)-Epigallocatechin-3-gallate modulates peripheral immunity in the MPTP-induced mouse model of Parkinson's disease.3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation by N-Acetylcysteine.
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P2860
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Relationship between alpha syn ...... kinson's disease pathogenesis.
@en
Relationship between alpha syn ...... kinson's disease pathogenesis.
@nl
type
label
Relationship between alpha syn ...... kinson's disease pathogenesis.
@en
Relationship between alpha syn ...... kinson's disease pathogenesis.
@nl
altLabel
Relationship between alpha syn ...... rkinson’s disease pathogenesis
@en
prefLabel
Relationship between alpha syn ...... kinson's disease pathogenesis.
@en
Relationship between alpha syn ...... kinson's disease pathogenesis.
@nl
P2093
P921
P1476
Relationship between alpha syn ...... kinson's disease pathogenesis.
@en
P2093
Hey Long Ching
J Mark Cooper
Kai-Yin Chau
P304
P356
10.1111/J.1471-4159.2009.06191.X
P407
P577
2009-05-29T00:00:00Z