Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats.
about
Interspecies scaling: is a priori knowledge of cytochrome p450 isozymes involved in drug metabolism helpful in prediction of clearance in humans from animal data?Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state.Prediction of hepatic clearance in human from in vitro data for successful drug development.Scaling basic toxicokinetic parameters from rat to man.Deleterious impact of a γ-aminobutyric acid type A receptor preferring general anesthetic when used in the presence of persistent inflammation.Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data.Prediction of human pharmacokinetics--evaluation of methods for prediction of volume of distribution.Prediction of human pharmacokinetics - renal metabolic and excretion clearance.Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.Prediction of volume of distribution at steady state in humans: comparison of different approaches.Interspecies metabolism and pharmacokinetic scaling of theophylline disposition.Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.Interspecies scaling: predicting clearance of drugs in humans. Three different approaches.Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.Reassessing models of hepatic extraction.Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken.Prediction of clearance in humans from in vitro human liver microsomes and allometric scaling. A comparative study of the two approaches.Prediction of changes in the clinical pharmacokinetics of basic drugs on the basis of octanol-water partition coefficients.Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats.Prospective allometric scaling: does the emperor have clothes?
P2860
Q30656662-6591A73E-FE5C-4444-A3FB-CF0D6F25F58AQ33188075-BD74D313-09F0-469D-83BC-418FBE037AFBQ33437736-DC6DBAFC-E58E-4BDA-A2B5-6A1662F139CBQ34635619-3E5F8F18-9099-47C0-928E-4750339B38A7Q35230763-2719CD9D-9E52-4A91-B593-B7F66BAB1BB7Q36718935-F38BEFC5-2DF7-4E0C-9198-80C4F4809E6DQ36947315-0F99AA0A-E2C3-44F3-85AB-C1410822ED16Q36988426-C1BD27AE-52E0-4B67-BA93-3BDD0C3A4964Q37008900-1D3928E9-CEE0-4C77-9AB2-21810C42E194Q38010485-F45CB7D4-20A3-47ED-BBCC-96AA22CFAFF4Q38020763-42F7DADC-9E2F-457A-99BA-EE013D536B05Q39313715-0575E90A-EC83-493F-81AD-F3237448882DQ39805145-37C6C685-4754-49B8-B89A-5BABFC792397Q39815802-3F2B12E7-A753-48E4-9C7F-521EB4F0EEDCQ41189275-BB284023-232C-4E18-9927-3FF997A7B0DFQ41958760-D9B89D7E-EE87-4164-BA77-6DBF69DCF2BAQ42704731-0CC9302C-819C-4AB1-B4E2-3C811EEA0E8FQ46730724-6016ACC2-F2FC-4AC6-AD8B-1D21BBFE9050Q48489003-D5F6572C-CBC3-48BA-BEB0-417F1660A1F8Q48640220-09A9553E-B999-4EA1-A347-BEDE939D141DQ48933554-B0FD8F2A-E917-4314-80E1-EF9A6D067E3FQ52920937-01537AAF-DFD7-4092-B9CC-7A2EEA8AC94C
P2860
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Prediction of the disposition ...... acokinetic parameters in rats.
@en
Prediction of the disposition ...... acokinetic parameters in rats.
@nl
type
label
Prediction of the disposition ...... acokinetic parameters in rats.
@en
Prediction of the disposition ...... acokinetic parameters in rats.
@nl
prefLabel
Prediction of the disposition ...... acokinetic parameters in rats.
@en
Prediction of the disposition ...... acokinetic parameters in rats.
@nl
P2093
P2860
P356
P1476
Prediction of the disposition ...... acokinetic parameters in rats.
@en
P2093
P2860
P2888
P304
P356
10.1007/BF01059331
P577
1985-10-01T00:00:00Z