Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.
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The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2C-terminal tensin-like (CTEN): a promising biomarker and target for cancerSolution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1Deleted in liver cancer protein family in human malignancies (Review)Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2ADLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanismFull activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activationFunctional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerTensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphomaDishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma.Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivoSolution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.Molecular physiology of the tensin brotherhood of integrin adaptor proteins.Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinomaFunctional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing.Analysis of chromosomal aberration (1, 3, and 8) and association of microRNAs in uveal melanoma.Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.GAP-independent functions of DLC1 in metastasis.Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.A DNA methylation-based definition of biologically distinct breast cancer subtypes.CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma.PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells
P2860
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P2860
Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Deleted in liver cancer 1 (DLC ...... or tumor-suppressive function.
@en
Deleted in liver cancer 1
@nl
type
label
Deleted in liver cancer 1 (DLC ...... or tumor-suppressive function.
@en
Deleted in liver cancer 1
@nl
prefLabel
Deleted in liver cancer 1 (DLC ...... or tumor-suppressive function.
@en
Deleted in liver cancer 1
@nl
P2093
P2860
P1433
P1476
Deleted in liver cancer 1 (DLC ...... or tumor-suppressive function.
@en
P2093
Frankie Chi Fat Ko
Irene Oi-Lin Ng
Judy Wai Ping Yam
Lo-Kong Chan
P2860
P356
10.1371/JOURNAL.PONE.0005572
P407
P577
2009-05-15T00:00:00Z