Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor.

Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor.

Item
http://www.wikidata.org/entity/Q39853044
Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Glucocorticoids and type 2 diabetes: from physiology to pathology11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects.Pharmacokinetic-pharmacodynamic studies of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor MK-0916 in healthy subjects.Is there sufficient evidence to consider the use of 11β-hydroxysteroid dehydrogenase type 1 inhibition in children?New perspectives on the development of antiobesity drugs.Safety, pharmacokinetics and pharmacodynamics of BI 135585, a selective 11β-hydroxysteroid dehydrogenase-1 (HSD1) inhibitor in humans: liver and adipose tissue 11β-HSD1 inhibition after acute and multiple administrations over 2 weeks.Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of (14)C-Labeled Inhibitors of 11β-HSD1.Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate.
P2860

Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor.

Item
http://www.wikidata.org/entity/Q39853044
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@en
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@nl
type
label
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@en
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@nl
prefLabel
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@en
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Population pharmacokinetic/pha ...... selective 11β-HSD1 inhibitor.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698