Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling.
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Molecular pathology of emerging coronavirus infectionsNidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activitiesCoronavirus virulence genes with main focus on SARS-CoV envelope geneFrom SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug designPapain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular SubstratesDeubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cellsStructural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseStructural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitinYeast based small molecule screen for inhibitors of SARS-CoVThe SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death.PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism.Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions.Pathogenesis of murine coronavirus in the central nervous system.Accessory protein 5a is a major antagonist of the antiviral action of interferon against murine coronavirus.Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1.Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence.An interaction between the nucleocapsid protein and a component of the replicase-transcriptase complex is crucial for the infectivity of coronavirus genomic RNA.Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals changes in the cytoplasmic, nuclear, and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virusCoronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signalingA chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronavirusesMurine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.Coronaviruses: an overview of their replication and pathogenesis.Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppressionIdentification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity.The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase.SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.RNA-RNA and RNA-protein interactions in coronavirus replication and transcriptionArterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production.Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets.Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO.
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P2860
Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@en
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@nl
type
label
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@en
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@nl
prefLabel
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@en
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@nl
P2093
P2860
P921
P356
P1433
P1476
Severe acute respiratory syndr ...... IRF3 and NF-kappaB signaling.
@en
P2093
Kiira Ratia
Matthew Frieman
Robert E Johnston
P2860
P304
P356
10.1128/JVI.02220-08
P407
P577
2009-04-15T00:00:00Z