Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.

Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.

Item
http://www.wikidata.org/entity/Q39869048
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strainPhenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effectsFrenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.Functional Characterization of a Ketoreductase-Encoding Gene med-ORF12 Involved in the Formation of a Stereospecific Pyran Ring during the Biosynthesis of an Antitumor Antibiotic Medermycin.Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitorsA diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis.Recent development of anticancer therapeutics targeting Akt.Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave.Pyranonaphthoquinones - isolation, biology and synthesis: an update.Expression, Crystallization and Preliminary X-ray Diffraction Analyses of Med-ORF10 in the Biosynthetic Pathway of an Antitumor Antibiotic Medermycin.The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.Exploring O-stannyl ketyl and acyl radical cyclizations for the synthesis of γ-lactone-fused benzopyrans and benzofurans.The value of pyrans as anticancer scaffolds in medicinal chemistry
P2860

Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.

Item
http://www.wikidata.org/entity/Q39869048
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@en
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@nl
type
label
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@en
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@nl
prefLabel
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@en
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Pyranonaphthoquinone lactones: ...... te a regulatory loop cysteine.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698