Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice.
about
Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating diseaseTheiler's virus infection: a model for multiple sclerosisTheiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J miceDNA vaccination against Theiler's murine encephalomyelitis virus leads to alterations in demyelinating disease.Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis.Role of individual T-cell epitopes of Theiler's virus in the pathogenesis of demyelination correlates with the ability to induce a Th1 response.Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus.CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.A spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope.Capsid-specific cytotoxic T lymphocytes recognize three distinct H-2D(b)-restricted regions of the BeAn strain of Theiler's virus and exhibit different cytokine profilesThe majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Differences in avidity and epitope recognition of CD8(+) T cells infiltrating the central nervous systems of SJL/J mice infected with BeAn and DA strains of Theiler's murine encephalomyelitis virusGenetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease.Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resistant mice infected with Theiler's virusAnticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice.Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosisAssociation between susceptibility to Theiler's virus-induced demyelination and T-cell receptor Jbeta1-Cbeta1 polymorphism rather than Vbeta deletion.Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens.
P2860
Q24613288-829D55F5-C45C-4A5B-A8E9-A472FD8FB403Q24629115-00746997-C970-4EC5-B8A0-26DF811EA9F0Q33496653-C2710E87-EAC6-4F12-BD35-F8F0C016772BQ33640182-58C4969B-C6CE-4FDA-ACF2-BFC1BE2A95A5Q33643385-3124D569-6521-406F-8ED8-DA37B7F5ECFEQ33785859-F23CB340-2CC3-4A57-8C49-F48E39606264Q33846745-9285B315-CB70-4C63-8E62-1FF0DA73FA52Q33873833-083D4451-CCDF-4E3E-ACBF-7628BB92A535Q34069130-70DC35EE-8D0A-4C7D-9692-BBA49B9580DDQ34333737-60FEA3E8-8C8C-44BB-AAE9-02CF184668A2Q34340904-7C2D007A-5BE1-4AC3-A594-84CE9021C047Q34356592-718178D6-C269-4705-8AD1-8CA088C612A9Q35768390-C8906096-8A67-4FDA-BE88-EA38E224BD9FQ35881226-035791AF-9A08-4A76-B810-2FA19A2595E6Q36315064-2D1CD1C9-D9E1-4CE8-80BD-054D8247949AQ36673418-B1EA11A0-2C72-4EA8-8C87-8A355AB445C8Q37628560-DD093C3E-EB6A-487B-BA0C-1D312D3A92EAQ39879582-B30BC0C2-CE55-47EB-A00D-52B9EA1EF291Q43242579-D720EE5F-62ED-4A52-A674-CE75B6F32AAD
P2860
Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@en
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@nl
type
label
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@en
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@nl
prefLabel
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@en
Identification of a major T-ce ...... nation-susceptible SJL/J mice.
@nl
P2093
P2860
P1433
P1476
Identification of a major T-ce ...... ination-susceptible SJL/J mice
@en
P2093
P2860
P304
P407
P577
1995-11-01T00:00:00Z