4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
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Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinomaRole of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlightHyaluronan, Inflammation, and Breast Cancer ProgressionHyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarizationIntercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes.CD44 and hyaluronan promote the bone morphogenetic protein 7 signaling response in murine chondrocytes.Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronanHyaluronan synthesis mediates the fibrotic response of keratocytes to transforming growth factor beta.4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expressionInhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells.Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress.4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1.The role of interleukin-10 and hyaluronan in murine fetal fibroblast function in vitro: implications for recapitulating fetal regenerative wound healing.Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo.Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts.Inhibition of Hyaluronic Acid Synthesis Suppresses Angiogenesis in Developing Endometriotic Lesions.Dietary supplement 4-methylumbelliferone: an effective chemopreventive and therapeutic agent for prostate cancer.Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facilityInhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitisHyaluronic acid synthesis is required for zebrafish tail fin regeneration.Monitoring enzymatic degradation of pericellular matrices through SERS stampingThe hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activityHyaluronan as a therapeutic target in human diseasesThe hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells.Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma.Synthesis of N-acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis.Hyaluronan synthesis and myogenesis: a requirement for hyaluronan synthesis during myogenic differentiation independent of pericellular matrix formationCell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signalingHeparin prevents intracellular hyaluronan synthesis and autophagy responses in hyperglycemic dividing mesangial cells and activates synthesis of an extensive extracellular monocyte-adhesive hyaluronan matrix after completing cell division.The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma.Hyaluronan, a ready choice to fuel regeneration: a mini-review.Therapeutic targeting of hyaluronan in the tumor stroma.
P2860
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P2860
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@en
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@nl
type
label
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@en
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@nl
prefLabel
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@en
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@nl
P2093
P1476
4-Methylumbelliferone inhibits ...... f hyaluronan synthase 2 and 3.
@en
P2093
Anne Kultti
Emma Pyöriä
Marjo Jauhiainen
Markku I Tammi
Raija H Tammi
Riikka Kärnä
Sanna Pasonen-Seppänen
P304
P356
10.1016/J.YEXCR.2009.03.002
P407
P50
P577
2009-03-13T00:00:00Z