Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2
about
Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolatesGene-specific inhibition of reovirus replication by RNA interference.The reovirus protein mu2, encoded by the M1 gene, is an RNA-binding protein.Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions.Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins.Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism.Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.Functional investigation of grass carp reovirus nonstructural protein NS80.Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2.Identification of functional domains in reovirus replication proteins muNS and mu2.Reovirus replication protein μ2 influences cell tropism by promoting particle assembly within viral inclusions.The reovirus mutant tsA279 L2 gene is associated with generation of a spikeless core particle: implications for capsid assembly.Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores.Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2.Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS.Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2.
P2860
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P2860
Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Identification and characteriz ...... tive in minor core protein mu2
@en
Identification and characteriz ...... ive in minor core protein mu2.
@nl
type
label
Identification and characteriz ...... tive in minor core protein mu2
@en
Identification and characteriz ...... ive in minor core protein mu2.
@nl
prefLabel
Identification and characteriz ...... tive in minor core protein mu2
@en
Identification and characteriz ...... ive in minor core protein mu2.
@nl
P2860
P1433
P1476
Identification and characteriz ...... tive in minor core protein mu2
@en
P2093
P2860
P304
P407
P577
1996-07-01T00:00:00Z