Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. - Wikidata - wikimedia - TriplyDB

Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.

Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.

http://www.wikidata.org/entity/Q39882524

about

Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi)ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy.RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer.Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.Isolation of Fully Human Antagonistic RON Antibodies Showing Efficient Block of Downstream Signaling and Cell Migration.Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines.Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo.The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells.RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.Vitamin D3-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity.A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells.The RON receptor tyrosine kinase is a potential therapeutic target in Burkitt lymphoma.Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancer RON kinase isoforms demonstrate variable cell motility in normal cells.MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteur d'Origine Nantais.MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8.Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer.Ezrin expression and cell survival regulation in colorectal cancer Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis.Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer.Expression of the receptor tyrosine kinase recepteur d'origine nantais and its association with tumor progression in hypopharyngeal cancer.Upregulation of recepteur d'origine nantais tyrosine kinase and cell invasiveness via early growth response-1 in gastric cancer cells.Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing.Qingchang Wenzhong Decoction Attenuates DSS-Induced Colitis in Rats by Reducing Inflammation and Improving Intestinal Barrier Function via Upregulating the MSP/RON Signalling Pathway.

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Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.

http://www.wikidata.org/entity/Q39882524

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

@en

Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

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type

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Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

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Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

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prefLabel

Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

@en

Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

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Journal of Biological Chemistry

P1476

Knockdown of Ron kinase inhibi ...... asis in human colon carcinoma.

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P2093

Alexander Beko

http://www.w3.org/2001/XMLSchema#string

Ashwani Rajput

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Charles Levea

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David M Keane

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Elizabeth A Sharratt

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Feng-Lei Sun

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Ivan Dominquez

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Jennie Hauser

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Jing Wang

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Julie L C Kan

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P2860

The Hallmarks of Cancer

Cross-talk between the proto-oncogenes Met and Ron

Identification of the ron gene product as the receptor for the human macrophage stimulating protein

RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP

Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.

High frequency of mutations of the PIK3CA gene in human cancers

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

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10912-10922

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10.1074/JBC.M809551200

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P433

16

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284

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19224914

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